Research Paper Volume 15, Issue 6 pp 2158—2169
Reduction of NgR in perforant path protects neuronal morphology and function in APP/PS1 transgenic mice
Figure 1. NgR reduction protects the neuronal morphology and number in APP/PS1 transgenic mice. (A) The coronal sections of the hippocampus were stained with an antibody against NeuN. (B) The numbers of the NeuN-positive cells in the hippocampus were quantified. (C) The neurons were observed under electron microscope. The images showed the hippocampal neurons in TG-vector mice and TG-shNgR mice, respectively. Data are presented as mean ± SEM. n = 3-4 male mice/group. The statistical analysis was performed by Student’s t test. *P < 0.05.