Research Paper Volume 15, Issue 9 pp 3791—3806

Figure 4. miR-497 overexpression increases the effect of 5-FU, CDDP and paclitaxel treatment in EC Cells. (A–C) Eca109 cells were treated with different concentrations of 5-FU, CDDP or paclitaxel as indicated, the cell viability was analyzed using CCK8 assay. Overexpression of miR-497 significantly increased chemo-sensitivity. (D–F) Forced expression of miR-497 in Kyse30 rendered cells more sensitive to 5-FU, CDDP or paclitaxel treatment. Data were representative of 3 independent experiments. * indicated significant difference at p<0.05, ** indicated significant difference at p<0.01.