Research Paper Advance Articles

Sig1R activates extracellular matrix-induced bladder cancer cell proliferation and angiogenesis by combing β-integrin


Figure 9. Sig1R mediates BEM-induced BC cell proliferation in vivo. (A) Xenograft model in nude mice. (B) Tumor growth curve of Sig1R-KD, Sig1R-KD, or Sig1R-KD T24 cell BC subcutaneous xenograft tumor. (C) The weight of dissected xenograft tumors in each group was assayed. (D) The IHC staining was performed to detect the expression levels of Sig1R, CD31, and PCNA, in harvested tumor tissues. *p < 0.05, **p < 0.01, and ***p < 0.001, scale bar = 100 μm.