Research Paper Volume 15, Issue 10 pp 4288—4303

DNMT1 regulates polarization of macrophage-induced intervertebral disc degeneration by modulating SIRT6 expression and promoting pyroptosis in vivo


Figure 3. Silencing DNMT1 or overexpressing SIRT6 can significantly inhibit the NPCs’ pyroptosis. (AC) represent the expression of pyroptosis markers: IL- 1β, IL-6, and IL-18 in the NPCs determined by ELISA. (D) Western blotting of NLRP3, ASC and caspase-1 pyroptosis markers.