Research Paper Volume 15, Issue 10 pp 4288—4303
DNMT1 regulates polarization of macrophage-induced intervertebral disc degeneration by modulating SIRT6 expression and promoting pyroptosis in vivo
Figure 6. DNMT1/SIRT6 axis can affect NPCs proliferation and apoptosis by regulating macrophage polarization. (A) apoptosis-related proteins including caspase-3, Bax, and Bcl-2 were detected by western blot (B) CCK-8 assay for cell viability.