Research Paper Advance Articles

Plasticity of adipose tissues in response to fasting and refeeding declines with aging in mice


Figure 3. Histological alterations of adipose tissue in the three groups of mice subjected to fasting and refeeding. The effects of fasting and refeeding on histological alterations of various adipose tissues in adult mice (A). The average area of adipocytes (μm2) in every 100-mm2 area range of various adipose tissues was quantified using the Image Pro Plus software (B) (n = 6-8). Expression of lipid metabolism-related genes in different white fat depots in adult and middle-age transitional mice under different feeding conditions. Differential expressions of lipid mobilization related genes (Atgl, Hsl) (C) in inguinal, epididymal and mesenteric adipose tissues were measured (n = 6–8). Scale bar represents 100 μm and all data are presented as the mean ± SEM. * p < 0.05; ** p < 0.01; *** p < 0.001 compared with control.