Research Paper Volume 15, Issue 10 pp 4391—4410

Hairy gene homolog increases nasopharyngeal carcinoma cell stemness by upregulating Bmi-1


Figure 2. Bmi-1 upregulation was associated with malignant tumor progression in NPC patients. (A) Representative images of Bmi-1 levels in clinical tissue biopsies from NPC patients with differing tumor-node-metastasis (TNM) stages, clinical stages and histological types. Low Bmi-1 expression was detected in T1 (a), N0 (c), M0 (e), stage I (g) and differentiated nonkeratinizing carcinoma (DNKC) (i) NPC biopsies, while high Bmi-1 expression was observed in T3 (b), N3 (d), M1 (f), stage IV (h) and undifferentiated carcinoma (UDC) (j) tumors. (B) The number and percentage of samples with high and low Bmi-1 levels according to various clinicopathological traits (χ2 test). (C) Cumulative overall survival curves of 98 NPC patients with high or low Bmi-1 levels. A log-rank test was used to calculate the P value.