Research Paper Volume 15, Issue 10 pp 4411—4428

Brevilin A shows an anti-tumor role in prostate cancer via the lncRNA H19/miR-194/E2F3 signaling pathway


Figure 8. The functions of Brevilin A and lncRNA H19 in the prostate cancer nude mouse xenograft model. DU145 cells, stably transfected with lncRNA H19 overexpression plasmids, were taken to construct a nude mouse xenograft model of prostate cancer, and Brevilin A was harnessed for treatment. The tumors were excised 28 days later. (A) The tumor volume. (B) The images of tumors. (C) The tumor masses. (D, E) Immunohistochemistry determined Ki67 and E2F3 expressions. (F, G) qRT-PCR examined the profiles of lncRNA H19 and miR-194. (H) Western blot was used for examining E2F3 protein level. ***P < 0.001 (vs. NC); &&P < 0.01, &&&P < 0.001 (vs. H19), n = 5.