Research Paper Volume 15, Issue 10 pp 4429—4443

Metformin inhibits ovarian granular cell pyroptosis through the miR-670-3p/NOX2/ROS pathway


Figure 7. Schematic overview of the anti-pyroptotic action of metformin in KGN cells. Metformin increases the levels of miR-670-3p, which in turn targets the CYBB 3’UTR and downregulates NOX2 expression, reduces ROS production, inhibits the activation of the NLRP3 inflammasome and ameliorates KGN cell pyroptosis.