Research Paper Volume 15, Issue 10 pp 4035—4050

Changes in macrophage immunometabolism as a marker of skeletal muscle dysfunction across the lifespan


Figure 4. Macrophages in middle-aged skeletal muscle tissue are involved in ECM remodeling and contribute to the onset of skeletal muscle aging. (A) Gastrocnemius/soleus histologies with Masson Trichromic dye of 8 mo. old, 10-14 mo. old, and 18 mo. old mice. Both 10x and 40x magnification images are shown. (B) Bar graph shows the results of the quantification of collagen staining area in each age group. N = 3 Per group.