Research Paper Volume 15, Issue 12 pp 5412—5425
Tumor-suppressive function and mechanism of miR-873-5p in glioblastoma: evidence based on bioinformatics analysis and experimental validation
Figure 6. miR-873-5p inhibits the tumorigenesis of GBM cells by downregulating the HMOX1/HIF1α/SPOP signaling axis in vivo. (A) Tumor volume of nude mice. (B) Tumor weight of nude mice. (C) Expression of miR-873-5p, HMOX1, HIF1α, and SPOP in the tumor tissues of mice detected by RT-qPCR. (D) Western blot of the HMOX1, HIF1α, and SPOP proteins in the tumor tissues of mice. (E) Western blot of the CCND1, E-cadherin, MYC, MMP-7, and N-cadherin proteins in the tumor tissues of mice. n = 10. *p < 0.05, compared to NC agomir-treated mice. #p < 0.05, compared to miR-873-5p agomir + oe-NC-treated mice.