Research Paper Volume 15, Issue 12 pp 5497—5513

Integrative analysis of single-cell and bulk RNA sequencing unveils the senescence landscape in ischemic stroke


Figure 2. Discovery of SRGs in rat MCAO model and human peripheral blood. (A) The volcano plot for DEGs of brain tissue in GSE163654. The genes related to cellular senescence were labeled. Red represents high gene expression and blue represents low expression. (B) The Venn plot for the distribution of DEGs. (C) The protein-protein interaction network for SRGs. (D) The heatmap for SRGs in GSE163654. (E) GO/KEGG pathway analysis and protein interaction network of SRGs. The color of the proteins corresponds to the pathway and the number shows the count of genes. (F) The violin plot for SRGs of human peripheral blood in GSE16561. *p < 0.05, **p < 0.01, ***p < 0.001.