Research Paper Volume 15, Issue 12 pp 5550—5568

Mettl3-mediated m6A modification plays a role in lipid metabolism disorders and progressive liver damage in mice by regulating lipid metabolism-related gene expression


Figure 1. Mettl3 expression is downregulated in liver tissues of patients and mice with obesity. (A) Mettl3 expression is downregulated in the liver of patients with obesity (with or without type 2 diabetes) compared to that in lean individuals from the GEO dataset (GSE15653). (B) The expression of Mettl3 is significantly negatively correlated with Cd36 in liver of obese hyperphagic mice fed with the high-fat diet and control mice from the GEO dataset (GSE43691). (CF) Relative expression of Mettl3 in the livers of ob/ob (C), db/db (D), NIAAA (E), and FFC (F) mice was detected by qRT-PCR. Data are presented as the mean ± SD. Abbreviation: ns: not significant; *P < 0.05; **P < 0.01; ***P < 0.001.