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Research Paper Volume 15, Issue 12 pp 5550—5568

Mettl3-mediated m6A modification plays a role in lipid metabolism disorders and progressive liver damage in mice by regulating lipid metabolism-related gene expression

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Figure 2. Generation of hepatocyte-specific Mettl3 knockout mice. (A) The offspring mice with different genotypes from intercrossing Mettl3flox/flox and heterozygous Alb-Cre mice. (B) The offspring mice with different genotypes from intercrossing Mettl3flox/wt; Alb-Cre and Mettl3flox/flox mice. (C) The offspring mice with different genotypes from intercrossing Mettl3flox/flox; Alb-Cre and Mettl3flox/flox mice. (D) PCR-based genotyping of genomic DNA collected from the main organs of METTL3 HKO mice and control mice.