Research Paper Volume 15, Issue 12 pp 5550—5568

Mettl3-mediated m6A modification plays a role in lipid metabolism disorders and progressive liver damage in mice by regulating lipid metabolism-related gene expression


Figure 4. Specific knockout of Mettl3 in hepatocytes results in downregulating lipid metabolism-related genes. (A) Principal component analysis (PCA) plot showing reproducibility among the replicates of each group. (B) Volcano plot showing the differential expression of protein-coding genes in the GSE176113 dataset. (CH) Gene set enrichment analysis (GSEA) plot of enrichment of indicated signatures in Mettl3 HKO livers using the C5 MSigDB database.