Research Paper Volume 15, Issue 12 pp 5550—5568

Mettl3-mediated m6A modification plays a role in lipid metabolism disorders and progressive liver damage in mice by regulating lipid metabolism-related gene expression


Figure 5. Multiple omics analyses identify the specific targets of lipid disorder caused by Mettl3-mediated m6A modification. (A) Venn diagram showing the number of overlapping Hypo-m6A-methylated mRNAs and downregulated genes in the liver of METTL3 HKO mice. Then the resultant 58 genes were annotated to GO term lipid metabolism and transport and obtained 12 genes. (B) Four-quadrant diagram showing the differentially methylated genes and differentially expressed genes in GSE142835 and GSE176113. (C, D) Peak distribution normalized to input in the genomic regions of Cyp7a1 (C) and Abcg8 (D) in control and METTL3 HKO mice in the GSE179680 dataset is shown. (E, F) Schematic representation of predicted positions of m6A motifs within Cyp7a1 (E) and Abcg8 (F) mRNA.