Research Paper Volume 15, Issue 12 pp 5550—5568
Mettl3-mediated m6A modification plays a role in lipid metabolism disorders and progressive liver damage in mice by regulating lipid metabolism-related gene expression
Figure 7. Genes related to lipid metabolism are significantly downregulated in the liver of METTL3 HKO mice. (A–E) qRT-PCR analysis of the mRNA expression of genes related to fatty acid oxidation (A), cholesterol efflux (B), lipid metabolic process (C), lipid transport (D), and lipid biosynthetic process (E) in the liver of METTL3 HKO mice and control mice. (F–G) Representative immunoblotting images (F) and quantitative results (G) for the potential target gene in the liver of METTL3 HKO mice and control mice. Data are presented as the mean ± SD. Abbreviations: FFA: free fatty acid; ns: not significant; *P < 0.05; **P < 0.01.