Research Paper Volume 15, Issue 12 pp 5569—5591

Figure 5. The immune landscape of SP100 family in PAAD. (A) The expression level of SP100/SP110/SP140 was positively correlated with the infiltration level of a variety of tumor infiltrating immune cells, including Act B, Tcm CD8 and Tem CD8, but SP140L was the opposite; (B–F) The expression level of SP100/SP110/SP140 was positively correlated with most immunomodulators, but SP140L was the opposite; (G) The expression of SP100 family was significantly different among the five immune subtypes; (H) The expression of SP100 family was positively correlated with the sensitivity of various targeting or chemotherapeutic drugs. (I) There are significant co-expression correlations between SP100 family members and several immune checkpoint genes, including CD44, HHLA2 and HAVCR2. ^*p < 0.05; ^**p < 0.01.