Research Paper Volume 15, Issue 12 pp 5698—5712

Sevoflurane upregulates neuron death process-related Ddit4 expression by NMDAR in the hippocampus


Figure 5. Six hub genes were enriched in biological process terms, and 4 hub genes were associated with cell death biological process terms. (A) Six hub genes enriched in biological process terms. (B) Expression of 6 hub genes between the control and sevoflurane-treated groups. (C) qPCR detection of Agt, Cdkn1a, Ddit4, Pdgfra, Rapgef3, and Rhob mRNA expression levels in the hippocampus of the mice that received 3% sevoflurane exposure for 4 h or the control mice. Sevoflurane indicates the mice received sevoflurane exposure. Control indicates that the mice were raised only under normal conditions. (D) Four hub genes associated with cell death biological process terms. The data shown are the means ± SDs, n = 3. *P < 0.05, **P < 0.01. (Green: Control group; Red: sevoflurane-treated group).