Research Paper Volume 15, Issue 12 pp 5826—5853

Identification and validation of a 7-genes prognostic signature for adult acute myeloid leukemia based on aging-related genes


Figure 7. Development, validation and clinical use of predicted nomogram. (A) Prognostic analysis of Nomogram. VIF indicated Variance inflation factor. (B) Construction of Nomogram according to prognostic factors of AML patients in training cohort. Values of prognostic risk Score (PRS) were calculated by 7-ARGs signature. (C) Sankey diagram of transitions from cytogenetics risk category to reclassification of 7-ARGs signature and Nomogram. (D) Analysis of survival relying on stratification of Nomogram. (E) Calibration curve of Nomogram at 1-, 2-, and 3-year. Discrimination with C-statistic at different time (F) and DCA plot at 1-, 2- and 3-year (GI) for Nomogram and clinical features (model with age alone or with age plus cytogenetics risk).