Editorial Volume 15, Issue 13 pp 5956—5958

Figure 1. Mitochondrial fitness sustains healthy muscle aging. Coordination of mitochondrial dynamics and mitophagy are two key events in the control of mitochondrial fitness. In this regard, high levels of the mitochondrial dynamics protein Mfn2, and the mitophagy protein BNIP3, are associated with an increase in mitochondrial fitness and determine a healthy muscle aging. In contrast, unhealthy muscle aging is associated to low levels of Mfn2 and BNIP3, which is characterized by mitochondrial dysfunction, inflammation, muscle atrophy and sarcopenia.