Hub gene identification and molecular subtype construction for <i>Helicobacter pylori</i> in gastric cancer via machine learning methods and NMF algorithm

Lianghua Luo; Ahao Wu; Xufeng Shu; Li Liu; Zongfeng Feng; Qingwen Zeng; Zhonghao Wang; Tengcheng Hu; Yi Cao; Yi Tu; Zhengrong Li

doi:doi:10.18632/aging.205053

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Research Paper Volume 15, Issue 21 pp 11782—11810

Hub gene identification and molecular subtype construction for Helicobacter pylori in gastric cancer via machine learning methods and NMF algorithm

Figure 9. Functional and pathway enrichment analysis of the hub genes. (A) Construction of a protein-protein interaction (PPI) network through using the GeneMANIA database. (B) The hub genes being involved in several key cancer-associated processes, such as epithelial-mesenchymal transition (EMT), receptor tyrosine kinase (RTK), cell cycle, apoptosis, etc. (C) The result of predicted miRNAs targeting hub genes using the GSCALite website.