Research Paper Volume 15, Issue 21 pp 11697—11719

Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model


Figure 5. Gene expression profiling revealed various patterns of changes in PFC and hippocampus of P301S mice at different ages. (AI) Bar graphs of mRNA levels in PFC and hippocampus of WT and P301S mice at 3 and 9 months (n: WT/Tau = 6/6 per group), which included: Category 1 (UP-DOWN) (AD, Nlgn1, Wnt7a, Syp, Stx1b); Category 2 (NO-DOWN) (E, F, Shank3, Snap25); Category 3 (NO-UP) (G, H, Rab34, Rab5a); and Category 4 (NO CHANGE) (I, Vamp2). #p < 0.1, *p < 0.05, **p < 0.01, ***p < 0.001, t-test.