Research Paper Volume 15, Issue 21 pp 11845—11859

Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway

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Figure 2. CAP alleviated DOX-induced myocardial injury. (A) Cross-sectional staining of mouse heart, HE staining. (B) Masson staining of Cross-sectional staining of mouse heart. Scale: 50 µM (C) Percentage analysis of collagen fibers (n = 6). (D) mRNA expression levels ofMYH7 (left) and BNP (right) in mouse heart tissue on day 4 after injection (n = 6). (E) KEGG disease enrichment map of mice in DOX and CAP+DOX groups (n = 3). Data are shown as the mean ± SEM. Statistical significance was determined using two-tailed student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001.