Research Paper Volume 15, Issue 21 pp 12330—12368

A robust six-gene prognostic signature based on two prognostic subtypes constructed by chromatin regulators is correlated with immunological features and therapeutic response in lung adenocarcinoma


Figure 5. Correlations of molecular prognostic subtype with clinical features and KEGG pathway enrichment. (A) Expression of 27 prognostic chromatin regulators between two clusters. (B) Comparison of clinical features between two clusters. Chi-square test showed the significant differences in T staging (p = 0.0083), N staging (p = 4e-04), age (p = 0.0021) and cancer status (p = 0.0273). (C) Gene set variation analysis. Totals of 184 KEGG pathways were significantly enriched between two clusters. (D) Gene set enrichment analysis. The top 26 significantly enriched KEGG pathways were shown between two clusters.