Research Paper Volume 15, Issue 21 pp 12330—12368

A robust six-gene prognostic signature based on two prognostic subtypes constructed by chromatin regulators is correlated with immunological features and therapeutic response in lung adenocarcinoma


Figure 6. Genomes alterations between two clusters. (A) Molecular features of genome alterations. There was higher aneuploidy score, nonsilent mutation rate, fraction altered of genome, number of segments and homologous recombination defects in the cluster 1. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001. (B) Gene mutation profiles between two clusters. The mutation frequencies of top 10 genes including TP53, TTN and MUC16 and so on had significant differences in two clusters, and there was higher mutation frequency in the cluster 1.