Research Paper Volume 15, Issue 21 pp 12413—12450

Construction and validation of a novel angiogenesis pattern to predict prognosis and immunotherapy efficacy in colorectal cancer


Figure 1. Landscape of the ARG genetic alterations in CRC. (A, B) Mutation frequencies of 36 ARGs in 399 and 137 patients with COAD and READ based on the TCGA cohort, respectively. (C) PPI network showing the interactions of ARGs (the minimum required interaction score was 0.4). (D) Expression distributions of DEGs between tumor and normal tissues. (E, F) Locations of CNV alterations in ARGs on 23 chromosomes and the frequencies of CNV gain, loss, and non-CNV among ARGs, respectively. (G) Expression distributions of DEGs between the high- and low-stage groups. *P < 0.05; **P < 0.01; ***P < 0.001.