Research Paper Volume 15, Issue 21 pp 12413—12450

Construction and validation of a novel angiogenesis pattern to predict prognosis and immunotherapy efficacy in colorectal cancer


Figure 9. Relationships between the ARG_score and therapeutic sensitivity. (A) Relationships between the ARG_score and chemotherapy and sensitivity to targeted inhibitor therapy. (B) The 3D structure of 6 potential target drugs screened out from the cMap database. (C) The IPS in the different ARG_score groups. (D, E) Proportion of patients with different treatment outcomes (bevacizumab therapy) in the low- and high-ARG_score groups. The proportion of response patients in the low ARG_score groups were significantly higher than that in the high-ARG_score groups in both the GSE53127 and GSE103668 cohorts. (FH) Patients with a high ARG_score exhibited poorer response outcomes after immunotherapy (anti-PD-1 therapy) using the GSE78220, GSE126044, and E-MTAB-3218 cohorts.