Research Paper Volume 15, Issue 22 pp 12998—13009

Figure 4. Overexpression of circFoxp1 enhances the growth of keloid and ECM deposition in vivo. (A) Representative images of HE staining and (B) Masson staining of keloid nodules in different intervention groups. (magnification, 100× and magnification, 200×). (C) Relative expression level of Ki67 and (D) Col1a1 observed in keloid grafts by IHC. (magnification, 200× and magnification, 400×). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001. (E) Quantitative RT-PCR (n = 6) showing transcript expression of related markers of ECM upregulated compared with the OE-NC of HSFs. (F) Western blot (n = 3) showing protein expression of related markers of ECM synthesis upregulated compared with the OE-NC of HSFs.