Research Paper Volume 15, Issue 24 pp 14720—14732
Meteorin-like protein elevation post-exercise improved vascular inflammation among coronary artery disease patients by downregulating NLRP3 inflammasome activity
Figure 5. Increased Metrnl alleviated PA-induced endothelial inflammatory responses via downregulating the ROS- NLR family pyrin domain containing 3 (NLRP3) signaling pathway. (A, B) Representative Western blot images of NLRP3 levels and normalized to GAPDH among PA-treated HUVECs, with or without Metrnl co-treatment. (C, D) Representative Western blot images of IL-1β levels and normalized to GAPDH among PA-treated HUVECs, with or without Metrnl co-treatment. Results are shown as mean ± SD. N =5/group. *P < 0.05 vs Con, #P < 0.05 vs PA. P<0.05 was statistically significant.