Research Paper Volume 15, Issue 23 pp 13628—13645
Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes
Figure 6. SIRT6 activation in chondrocytes from older human donors and mice. (A) Chondrocytes derived from cadaveric ankle cartilage of older donors (>70 years) were treated with 20 μM MDL-800 or vehicle (DMSO) for 48 hours. Stats by paired t-test. (B) Murine chondrocytes were isolated and treated for 48 hours with DMSO or 20 μM MDL-800. Analysis by two-way ANOVA showed significant effects of age, treatment, and their interaction. Asterisks denote significant treatment effects by Sidak’s multiple comparisons test, with *p < 0.05, **p < 0.01, ***p < 0.001.