Research Paper Volume 16, Issue 3 pp 2194—2231

Generating detailed intercellular communication patterns in psoriasis at the single-cell level using social networking, pattern recognition, and manifold learning methods to optimize treatment strategies


Figure 5. Hair follicle-psoriasis axis at the single cell level. (A) Significant ligand-receptor pairs between different subtypes of cells in psoriatic and normal skin. The size of the circles represents significance, and the colour represents the magnitude of the probability of communication between subtypes of cells. (B) Diagram of the “hair follicle-psoriasis axis” at the single cell level. Hair follicles release APP, LAMC1 or COL4A2, which communicates with resident immune cells such as melanocytes, mast cells and myeloid cells, thereby activating the immune “garrison” in the local area.