Research Paper Volume 16, Issue 3 pp 2563—2590

Integrative analysis confirms TPX2 as a novel biomarker for clinical implication, tumor microenvironment, and immunotherapy response across human solid tumors


Figure 13. Knockdown of TPX2 inhibited proliferation and migration of LUAD. (A) TPX2 mRNA expression levels were higher in 11 LUAD tissues than that in matched normal tissue samples. Y-axis data presents relative expression (normalized to GAPDH; calculated using the 2−ΔΔCt method). (B) Immunohistochemical analysis of TPX2 in LUAD tissues. Representative images are shown. (C) CCK8 assay suggested that knockdown of TPX2 inhibited the proliferation of A549 cells. (D) The wound healing assay suggested that knockdown of TPX2 reduced cell migration of A549 cells. *p<0.05, **p<0.01.