Research Paper Volume 16, Issue 3 pp 2715—2735

Integrated single-cell and bulk characterization of branched chain amino acid metabolism-related key gene BCAT1 and association with prognosis and immunogenicity of clear cell renal cell carcinoma


Figure 5. Mutation and immunotherapeutic responses of BMS groups. (A, B) Waterfall plots of somatic mutations in tumors in high-and low-BMS groups. (C) Differential expression of Tumor Mutation Burden (TMB) between high- and low-BMS groups. (D) Survival analysis between high- and low-TMB groups. (E) Survival analysis of distinct groups stratified by both TMB and BMS. (F) Differential expression of immunosuppressive checkpoints between high- and low-BMS groups. (GJ) The relative probability of response to anti-CTLA4 and/or anti-PD1 combination immunotherapy between high- and low-BMS groups. Wilcox test was used, and the asterisks represent the statistical P-value (*p <0.05, ** p <0.01, *** p <0.001).