Research Paper Volume 16, Issue 3 pp 2715—2735

Integrated single-cell and bulk characterization of branched chain amino acid metabolism-related key gene BCAT1 and association with prognosis and immunogenicity of clear cell renal cell carcinoma


Figure 7. Comparison of immune cells of ccRCC patients between high- and low-BCAT1 groups. (A) Samples in the high-BCAT1 group exhibited higher ESTIMATE, stromal, and immune scores than the low-BCAT1 group. (B) Correlation analysis between BCAT1 expression and immune infiltrating cells. (C) Abundances of main immunosuppressive infiltrating cells (MDSCs, macrophages, and Tregs) in tumor microenvironment (TME) in two groups. (D) Differential expression of common immune checkpoint molecules (PDL1, CD96, and PDCD1LG2) between high- and low-BCAT1 groups. (E) Correlation between the expression of BCAT1 and common immune checkpoint molecules. Wilcox test was used, and the asterisks represent the statistical P-value (*p <0.05, ** p <0.01, *** p <0.001).