Figure 1. Reversal of cisplatin-induced ovarian dysfunction and estrous cycle by metformin. (A) Schematic description of the experimental design. (B) Percentage of regular and irregular estrous cycles in each group (N=15). (C–E) Estrous cycle of each group. (F–H) Serum E2, FSH and AMH of following the administration of each group. *p < 0.05, **p < 0.01, ***p < 0.001.