Metformin mitigates cisplatin-induced ovarian damage through inhibiting the pyroptosis of granulosa cells via ROS/TXNIP/NLRP3 signaling pathway

Bo Wang; Jian Li; Qianyu Zhang; Yuting Li; Wu Ren; Du He

doi:doi:10.18632/aging.205659

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Withdrawal Notice

This paper was originally published in Aging Advance Online Publications on March 14, 2024.

In compliance with Aging's withdrawal policy, the paper was withdrawn in its entirety. It will not appear in Aging internal or any external indexes or archives.

WITHDRAWN: Metformin mitigates cisplatin-induced ovarian damage through inhibiting the pyroptosis of granulosa cells via ROS/TXNIP/NLRP3 signaling pathway

Figure 4. Reversal of cisplatin-induced acute ovarian damage by metformin. (A) Bulk sequencing reveals genes significantly upregulated or downregulated by metformin in alleviating ovarian damage. (B) GO terms enriched based on DEGs between the Cis group and Cis+Met groups. (C, D) Immunofluorescence of ROS after treatment in each group (×40). (E, F) Western blot analysis of NLRP3 and TXNIP protein expressions in ovaries treated with different medication regimens. *p < 0.05, **p < 0.01, ***p < 0.001.