Research Paper Volume 16, Issue 19 pp 12781—12805

Figure 1. The clinical correlation of ALKBH7 expression and the modification related to ALKBH7 expression in pan cancer, especially in HNSC. (A) Differential expression of ALKBH7 in 33 cancer types and (B) in paired tumor and normal tissues of 22 cancer types from the TCGA dataset. (C) The expression levels of ALKBH in tumor tissue and adjacent normal tissue from HNSC patients. (D) Differential expression of ALKBH7 in HNSC from various datasets. (E) Representative immunohistochemical images of ALKBH7 expression in HNSC and adjacent tissues from Second Affiliated Hospital of Naval Medical University, scale bar = 100 μm (left); 20 μm (right). (F) Western blotting of ALKBH7 differential expression in tumor tissue and adjacent normal tissue from HNSC patients. (G) Quantification of the H-score for ALKBH7 protein expressed level assessed by immunohistochemical assay. (H) Quantitative ratio of gray value for ALKBH7 protein expressed level assessed by western blotting. (I) Univariate Cox regression of ALKBH7 for OS in pan-cancers. (J) Correlation between ALKBH7 expression and OS in HNSC patients from TCGA dataset. (K) The correlation between ALKBH7 expression and DNA methylation degree in pan cancer. (L) The correlation between ALKBH7 expression and RNA modification regulator expression in pan cancer. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001.