Research Paper Volume 17, Issue 6 pp 1544—1570

Figure 1. Increased KHDC4 levels are associated with the development of advanced prostate cancer. (A) The volcano plot illustrates an elevation in KHDC4 levels among patients in the late stage of TCGA-PRAD. (B) The associated expression intensity of KHDC4 in patients from TCGA-PRAD. (C) The correlated expression levels of KHDC members in patients from TCGA-PRAD. (D) The correlated expression intensity of KHDC4 in normal solid tissue and primary prostate tumor. (E) The difference in the level of KHDC4 between late-stage or lymph node metastasis in TCGA-PRAD patients. (F) The correlation of KHDC4 levels with advanced prostate cancer across different sources of prostate cohorts (GSE21032, GSE35988, GSE6919). (G) The correlation of KHDC4 levels with prognosis values in cancer across different cohort sources. (H) KHDC 4 expression levels across diverse racial backgrounds. (I) Analysis of single-cell sequencing profiles (GSE176031) reveals the relative expression intensity of KHDC4 across different cell types. (J) The prognostic impact of KHDC4 on overall survival and disease-free survival rates in prostate cancer.