ࡱ> }| 8bjbj 4H8 $drtttttt$WT...jr.r...@l[ߢ$ .^0.M.M.M.0..M : p53 GeneSwitch over-expression experiments MaleM-FTarget transgeneGrN SD Mean life span Mean CI %( Med life span Med CI %( Max life span Max CI %(P-valSig7-9+L-A-12014.2584.6NA90NA98NANANAL+A-12322.4878.44(4.77 - (2.7886(9.58 - (1.5898(3.67 - (2.280.204__L-A+11910.9483.08(4.76 - 1.2586(7.34 - (1.9594(8.41 - (1.596.58 (10-3*16-9p53-WT[Ex]L-A-12214.7671.11NA72NA86NANA NAL+A-0(NANANANANANANANANAL-A+11712.5475.382.36 - 10.37785.83 - 15.51901.67 10.116.97 (10-3*18-9p53-Ct[AF51]L-A-12313.7782.05NA86NA95.6NANA NAL+A-12114.5979.72(6.11 - 0.7780(14.59 - (6.9796(4.65 - 6.520.159_L-A+11811.1579.71(5.73 - 0.5578(12.89 - (9.3096(4.01 - 4.570.032_19-9p53-Ct[B440]L-A-9913.0576.71NA78NA90NANANAL+A-12518.4761.7(23.45 - (15.2866(18.34 - (10.1880(19.48 - (5.978.16 (10-12***L-A+12716.173.1(8.26 - (0.7976(6. 88 - (1.9388.8(7.08 - 9.280.194__20-9p53-259HL-A-11813.8671.54NA72NA88NANANAL+A-11916.9267.73(10.46 - (0.7270(5.33 - 0.0084(10.19 - 2.220.069__L-A+12510.4168.9(7.11 - (0.0270(2.77 - 1.7678(15.77 - (5.532.11 (10-3* p53 GeneSwitch over-expression experiments FemaleM-FTarget transgeneGrN SD Mean life span Mean CI %( Med life span Med CI %( Max life span Max CI %(P-valSig7-9+L-A-1169.6492.02NA94NA102NANANAL+A-1248.6191.97(3.33 - (0.7294(2.88 - 2.79106(1.41 - 3.622.55 (10-2__L-A+12115.7494.690.866 - 2.7294(4.76 - 0.001042.33 7.413.10 (10-3*16-9p53-WT[Ex]L-A-11916.0988.35NA94NA100NANANAL+A-3(5.0391.33NA92NA95.2NANANAL-A+10122.0774.02(21.11 - (11.6180(23.06 - (8.6998(3.39- 2.092.21 (10-6***18-9p53-Ct[AF51]L-A-1238.86192.2NA94NA102NANANAL+A-12320.0881.82(14.90 - (8.0386(12.87 - (5.66100(5.59 - (1.963.40 (10-3*L-A+12516.5389.18(6.71 - (0.35940.00 - 3.19104(3.83 - 2.288.57 (10-1__19-9p53-Ct[B440]L-A-12713.5486.3NA90NA98NANANAL+A-12522.3564.56(29.62 - (20.8370(26.06 - (18.6885.2(16.43 - (7.000***L-A+12514.3989.311.96 - 6.81944.38 - 9.121000.35 - 4.094.72 (10-2__20-9p53-259HL-A-1198.49575.39NA76NA84NANANAL+A-12522.0270.24(11.94 - (2.4976(3.71 - 5.72881.80 - 8.562.02 (10-1__L-A+11910.9880.664.09 - 9.72824.52 - 14.04924.26 - 13.184.05 (10-8*** 123~  & ' . / 7 8 @ A I J R S a b y z   c d f h k l   »۱ jh5b;CJH* h5b;CJH* h5b;CJH* jh5b;CJ j-h5b;CJ h5b;CJ jDh5b;5CJh5b;h5b;5CJH* h5b;5CJF1237HKMRi $Ifgd Vkd$$Ifl0L$'% t'644 layt $If]gd kdw$$Ifl La  / vf!$'l=]G& t'6((((44 layt          & 4 7 F I X ^ Ff $Ifgd $$Ifa$gd ^ a b c d i m s y Ffc $$Ifa$gd Ff $Ifgd            ! % + 1 > A Ff $$Ifa$gd Ff  $Ifgd A N Q ^ i k l q ~ Ff $$Ifa$gd Ffg $Ifgd      " 1 4 A G I J O \ a d Ffk $$Ifa$gd Ff $Ifgd  " # + , 4 5 I J      2 3 k l      F G H ҿ jDh5b;5CJh5b;5CJH* h5b;5CJh h5b;CJH* jh5b;CJh5b; j-h5b;CJ h5b;CJKd j p s v y |  Ff' $$Ifa$gd Ff$ $Ifgd      ) / 2 3 8 A F J P V Y \ _ b e h k l Ff/ $$Ifa$gd Ffo+ $Ifgd l m n s w }   Ff2 $Ifgd $$Ifa$gd      F G H L ] ` b g ~ Vkd8$$Ifl0L#%$ t&644 layt $If]gd Ffs6 $Ifgd  $%;<CDLM]^oprtxy34KLTU^_ghpq  !89@A jh5b;CJH* h5b;CJH* jh5b;CJ j-h5b;CJ h5b;CJh5b; jDh5b;5CJ h5b;5CJL $Ifgd  kd79$$Ifl LR  A` #% l=\0T t&6((((44 layt  !$%&',05;ILY]juFf; $Ifgd $$Ifa$gd uxyz{Ff#C $$Ifa$gd Ffu? $Ifgd  "%*-03456;?EK[^FfyJ $$Ifa$gd FfF $Ifgd ^mp|FfQ $$Ifa$gd Ff'N $Ifgd  !"#(,28FIUYfqtuzFf+Y $$Ifa$gd Ff}U $Ifgd AYZklnptuMNPRVW,-/168h5b; h5b;CJH* jh5b;CJ j-h5b;CJ h5b;CJ2Ff` $$Ifa$gd Ff\ $Ifgd  ),8<HSVW\ejntz}Ffg $$Ifa$gd Ff/d $Ifgd  '2Ffk $Ifgd $$Ifa$gd 2678Ff3o $Ifgd 21h:pB=/ =!"#$% u$$If!vh5%5#v%#v:V l t'65%5/ ayt %$$If!v h55l5=55]5G5&55 5 #v#vl#v=#v#v]#vG#v&#v#v #v :V l t'655l5=55]5G5&55 5 / ayt g$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V lC t'655l5=55]5@555 f5 5 5 5 / ayt Kkd$$IflC" La  / ov6f!$'l=]@f t'6444444 layt _$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'6,55l5=55]5@555 f5 5 5 5 ayt KkdT$$Ifl" La  / ov6f!$'l=]@f t'6444444 layt _$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'6,55l5=55]5@555 f5 5 5 5 ayt Kkd $$Ifl" La  / ov6f!$'l=]@f t'6444444 layt Y$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'655l5=55]5@555 f5 5 5 5 ayt Kkd $$Ifl" La  / ov6f!$'l=]@f t'6444444 layt _$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V lZ t'6,55l5=55]5@555 f5 5 5 5 ayt KkdX$$IflZ" La  / ov6f!$'l=]@f t'6444444 layt _$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'6,55l5=55]5@555 f5 5 5 5 ayt Kkd$$Ifl" La  / ov6f!$'l=]@f t'6444444 layt Y$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'655l5=55]5@555 f5 5 5 5 ayt Kkd$$Ifl" La  / ov6f!$'l=]@f t'6444444 layt _$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'6,55l5=55]5@555 f5 5 5 5 ayt Kkd\$$Ifl" La  / ov6f!$'l=]@f t'6444444 layt _$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'6,55l5=55]5@555 f5 5 5 5 ayt Kkd $$Ifl" La  / ov6f!$'l=]@f t'6444444 layt Y$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'655l5=55]5@555 f5 5 5 5 ayt Kkd"$$Ifl" La  / ov6f!$'l=]@f t'6444444 layt _$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'6,55l5=55]5@555 f5 5 5 5 ayt Kkd`&$$Ifl" La  / ov6f!$'l=]@f t'6444444 layt _$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'6,55l5=55]5@555 f5 5 5 5 ayt Kkd*$$Ifl" La  / ov6f!$'l=]@f t'6444444 layt Y$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'655l5=55]5@555 f5 5 5 5 ayt Kkd-$$Ifl" La  / ov6f!$'l=]@f t'6444444 layt _$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'6,55l5=55]5@555 f5 5 5 5 ayt Kkdd1$$Ifl" La  / ov6f!$'l=]@f t'6444444 layt _$$If!v h55l5=55]5@555 f5 5 5 5 #v#vl#v=#v#v]#v@#v#v#v f#v #v #v #v :V l t'6,55l5=55]5@555 f5 5 5 5 ayt Kkd5$$Ifl" La  / ov6f!$'l=]@f t'6444444 layt u$$If!vh5$5#v$#v:V l t&65$5/ ayt %$$If!v h55h5=55\5&55y5 }5 #v#vh#v=#v#v\#v&#v#vy#v }#v :V l t&65 5l5=55\5055T5 5 / ayt g$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V lC t&65 5l5=55\5@55x5 :5 5 5 5 / ayt Kkd^:$$IflC" LR  [A` #% l=\@x: t&6444444 layt _$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&6,5 5l5=55\5@55x5 :5 5 5 5 ayt Kkd>$$Ifl" LR  [A` #% l=\@x: t&6444444 layt _$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&6,5 5l5=55\5@55x5 :5 5 5 5 ayt KkdA$$Ifl" LR  [A` #% l=\@x: t&6444444 layt Y$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&65 5l5=55\5@55x5 :5 5 5 5 ayt KkdpE$$Ifl" LR  [A` #% l=\@x: t&6444444 layt _$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&6,5 5l5=55\5@55x5 :5 5 5 5 ayt KkdI$$Ifl" LR  [A` #% l=\@x: t&6444444 layt _$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&6,5 5l5=55\5@55x5 :5 5 5 5 ayt KkdL$$Ifl" LR  [A` #% l=\@x: t&6444444 layt Y$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&65 5l5=55\5@55x5 :5 5 5 5 ayt KkdtP$$Ifl" LR  [A` #% l=\@x: t&6444444 layt _$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&6,5 5l5=55\5@55x5 :5 5 5 5 ayt KkdT$$Ifl" LR  [A` #% l=\@x: t&6444444 layt _$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&6,5 5l5=55\5@55x5 :5 5 5 5 ayt KkdW$$Ifl" LR  [A` #% l=\@x: t&6444444 layt Y$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&65 5l5=55\5@55x5 :5 5 5 5 ayt Kkdx[$$Ifl" LR  [A` #% l=\@x: t&6444444 layt _$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&6,5 5l5=55\5@55x5 :5 5 5 5 ayt Kkd _$$Ifl" LR  [A` #% l=\@x: t&6444444 layt _$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&6,5 5l5=55\5@55x5 :5 5 5 5 ayt Kkdb$$Ifl" LR  [A` #% l=\@x: t&6444444 layt Y$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&65 5l5=55\5@55x5 :5 5 5 5 ayt Kkd|f$$Ifl" LR  [A` #% l=\@x: t&6444444 layt _$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&6,5 5l5=55\5@55x5 :5 5 5 5 ayt Kkd$j$$Ifl" LR  [A` #% l=\@x: t&6444444 layt _$$If!v h55h5=55\5@55x5 .5 5 5 }5 #v#vh#v=#v#v\#v@#v#vx#v .#v #v #v }#v :V l t&6,5 5l5=55\5@55x5 :5 5 5 5 ayt Kkdm$$Ifl" LR  [A` #% l=\@x: t&6444444 layt j 666666666vvvvvvvvv666666>6666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ OJPJQJ_HmH nH sH tH L`L 5b;Normal$CJOJPJQJ^J_HmH sH tH DA D Default Paragraph FontRi@R 0 Table Normal4 l4a (k ( 0No List PK![Content_Types].xmlj0Eжr(΢Iw},-j4 wP-t#bΙ{UTU^hd}㨫)*1P' ^W0)T9<l#$yi};~@(Hu* Dנz/0ǰ $ X3aZ,D0j~3߶b~i>3\`?/[G\!-Rk.sԻ..a濭?PK!֧6 _rels/.relsj0 }Q%v/C/}(h"O = C?hv=Ʌ%[xp{۵_Pѣ<1H0ORBdJE4b$q_6LR7`0̞O,En7Lib/SeеPK!kytheme/theme/themeManager.xml M @}w7c(EbˮCAǠҟ7՛K Y, e.|,H,lxɴIsQ}#Ր ֵ+!,^$j=GW)E+& 8PK!Ptheme/theme/theme1.xmlYOo6w toc'vuر-MniP@I}úama[إ4:lЯGRX^6؊>$ !)O^rC$y@/yH*񄴽)޵߻UDb`}"qۋJחX^)I`nEp)liV[]1M<OP6r=zgbIguSebORD۫qu 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