ࡱ> jli_ bjbj,E,E ?2N/N/    8BVT lrtttttt$_DH6rrs(F^0UnR &U$x  : Appendix Table A5. Efficacy of all available interventions according to class-level Bayesian network analysis 1st-gen ET 0.96 (0.54-2.14)0.63 (0.24-1.68)1.30 (0.56-2.98)1.14 (0.47-3.43)NANA0.74 (0.24-2.20)NA0.63 (0.18-2.38)NA1.01 (0.58-1.72)0.77 (0.30-2.09)1.07 (0.39-2.97)0.97 (0.48-2.50)1.25 (0.73-2.07)2nd-gen ET0.66 (0.18-1.92)1.34 (0.41-3.58)1.17 (0.38-3.90)NANA0.77 (0.19-2.47)NA0.66 (0.14-2.59)NA1.05 (0.39-2.24)0.78 (0.24-2.48)1.12 (0.29-3.40)1.01 (0.52-2.00)1.27 (0.69-2.32)1.02 (0.47-2.26)3rd-gen ET2.06 (0.56-7.47)1.79 (0.52-8.36)NANA1.17 (0.26-5.15)NA1.00 (0.20-5.26)NA1.59 (0.52-4.90)1.20 (0.33-5.08)1.71 (0.42-7.03)1.52 (0.49-6.31)1.42 (0.71-2.83)1.14 (0.49-2.75)1.12 (0.44-2.82)ET+aVEGFR0.88 (0.26-3.56)NANA0.56 (0.15-2.26)NA0.48 (0.11-2.31)NA0.77 (0.29-2.10)0.59 (0.18-2.23)0.83 (0.22-3.08)0.75 (0.26-2.75)0.87 (0.21-3.51)0.70 (0.16-3.09)0.68 (0.15-3.18)0.62 (0.13-2.88)MT+ETNANA0.66 (0.13-2.40)NA0.56 (0.10-2.46)NA0.89 (0.26-2.41)0.67 (0.17-2.46)0.95 (0.20-3.42)0.86 (0.24-2.98)0.63 (0.11-3.65)0.51 (0.08-3.09)0.50 (0.08-3.13)0.45 (0.07-2.95)0.73 (0.08-7.14)IT+Plat NANANANANANANANANA1.19 (0.20-6.93)0.95 (0.15-5.94)0.94 (0.15-5.92)0.84 (0.13-5.58)1.36 (0.15-13.40)1.87 (0.53-6.70)IT+aVEGFR+PlatNANANANANANANANA0.92 (0.44-1.97)0.74 (0.31-1.88)0.73 (0.30-1.88)0.65 (0.24-1.85)1.07 (0.22-5.26)1.45 (0.24-9.65)0.77 (0.12-5.08)ET+PlatNA0.85 (0.43-1.78)NA1.37 (0.53-3.58)1.03 (0.26-4.72)1.46 (0.33-6.42)1.31 (0.38-5.88)0.73 (0.20-2.64)0.58 (0.15-2.31)0.57 (0.15-2.28)0.51 (0.12-2.21)0.84 (0.13-5.74)1.14 (0.35-3.77)0.61 (0.18-2.04)0.79 (0.19-3.16)aVEGFR+PlatNANANANANANA1.24 (0.42-3.85)1.00 (0.30-3.44)0.87 (0.24-3.38)1.44 (0.24-8.64)1.96 (0.27-15.20)1.05 (0.14-8.14)1.35 (0.59-3.07)1.71 (0.34-9.10)0.84 (0.17-4.34)ET+aVEGFR+PlatNA1.60 (0.48-5.10)1.20 (0.26-6.20)1.70 (0.32-8.68)1.54 (0.37-7.99)1.46 (0.47-4.73)1.17 (0.34-4.28)1.16 (0.32-4.41)1.04 (0.28-4.09)1.69 (0.28-10.60)2.32 (0.28-19.00)1.24 (0.15-10.40)1.60 (0.40-6.39)2.02 (0.36-11.40)1.19 (0.23-5.84)ET+CTNANANANA0.41 (0.28-0.61)0.33 (0.19-0.62)0.33 (0.18-0.61)0.29 (0.13-0.65)0.48 (0.11-2.06)0.65 (0.12-3.63)0.35 (0.06-1.98)0.45 (0.22-0.90)0.57 (0.17-1.94)0.33 (0.11-0.97)0.28 (0.08-0.94)Plat 0.76 (0.27-2.43)1.07 (0.34-3.40)0.97 (0.41-2.89)1.53 (0.61-3.87)1.23 (0.43-3.57)1.21 (0.41-3.67)1.08 (0.34-3.48)1.77 (0.33-9.37)2.42 (0.34-17.60)1.29 (0.18-9.49)1.66 (0.50-5.38)2.11 (0.43-10.30)1.23 (0.29-5.19)1.04 (0.23-4.53)3.69 (1.34-10.01)CT 1.41 (0.33-5.34)1.29 (0.38-4.70)0.56 (0.17-1.85)0.45 (0.13-1.68)0.44 (0.12-1.67)0.40 (0.10-1.59)0.65 (0.11-4.08)0.88 (0.11-7.50)0.47 (0.06-4.04)0.61 (0.15-2.47)0.77 (0.14-4.51)0.45 (0.09-2.24)0.38 (0.07-2.00)1.35 (0.40-4.75)1.13 (0.31-4.46)WBRT 0.90 (0.27-3.77)0.50 (0.27-0.89)0.40 (0.21-0.73)0.39 (0.16-0.91)0.35 (0.14-0.85)0.57 (0.12-2.59)0.79 (0.12-4.90)0.42 (0.06-2.63)0.54 (0.20-1.36)0.69 (0.16-2.72)0.40 (0.11-1.37)0.34 (0.09-1.19)1.20 (0.58-1.19)0.32 (0.10-0.95)0.88 (0.22-3.27)Placebo  Results for PFS are shown in blue-colour cells, results for OS are in gray-color cells. Comparisons should be read from left to right and the estimate is in the cell in common between the column-defining drugs and the row-defining treatment. For PFS and OS, HRs (and 95% CI) less than 1 favour the column-defining treatment. To obtain HRs for comparisons in the opposite direction, reciprocals should be taken. Significant results are in bold and underscored. Abbreviations: 1st-gen ET, first generation EGFR-TKI; 2nd-gen ET, second generation EGFR-TKI; 3rd-gen ET, third generation EGFR-TKI; ET+aVEGFR, EGFR-TKI+anti-VEGFR; MT+ET, MET-TKI+EGFR-TKI; IT+Plat, immunotherapy+platinum-based therapy; IT+aVEGFR+Plat, immunotherapy+anti-VEGFR+platinum-based therapy; ET+Plat, EGFR-TKI+platinum-based therapy; aVEGFR+Plat, anti-VEGFR+platinum-based therapy; ET+aVEGFR+Plat, EGFR-TKI+anti-VEGFR+platinum-based therapy; ET+CT, EGFR-TKI+cytotoxic therapy; Plat, platinum-based therapy; CT, cytotoxic therapy, WBRT, whole-brain radiotherapy; PFS, progression-free survival; OS, overall survival; HR, hazard-ratio, CI, confidence interval.     mnoprs1 2 C D F G     v w 3 4 < = pqֿzzzzzzzzzzzgg%hyrh-h`5>*CJKHOJQJ\ h /h-h`hyrh-h`CJKHOJQJhCJKHOJQJo(hhCJKHOJQJhCJKHOJQJ hSh-h`-hSh-h`CJOJQJaJfHq hSh-h`CJOJQJaJ3hSh-h`5CJOJQJaJfHo(q (no{ 1 2 C N _ p Ff7 $$1$Ifa$gd=gd-h`   ! 2 C F I Z ] n q FfFfs $$1$Ifa$gd=     / 2 C T e v w  Ff $$1$Ifa$gd= " 3 4 E V g x   $ Ffc!Ff' $$1$Ifa$gd=$ ' * - 0 3 6 9 < = N _ p )Ff-Ff' $$1$Ifa$gd=):K\m~&7HYhk|Ff4 $$1$Ifa$gd=|*;M^dgjmpqFf@FfS: $$1$Ifa$gd= ,2CTefw#59J[\FfMFfF $$1$Ifa$gd= ,ef[\PQ.HIO+-.5RTU]z|}ҽwokokokokwh0jh0Uh-h`h-h`CJaJ&hB*CJKHOJQJaJo(ph)hhB*CJKHOJQJaJph#hB*CJKHOJQJaJph)hyrh-h`B*CJKHOJQJaJph h-h`o( h /h-h`%hyrh-h`5>*CJKHOJQJ\hyrh-h`CJKHOJQJ%\m~(9?PQbs FfCS $$1$Ifa$gd= .?HIgd vWD^v`gd-h`FfY $$1$Ifa$gd==&P 182P0:p-h`X rB!9"9#9$9%S 5$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ /  / Bap֖yt-h`Tkd$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`Tkd.$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`Tkdj $$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`Tkd$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`Tkd$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`Tkd$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`TkdZ%$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`Tkd+$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`Tkd1$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`Tkd8$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`TkdJ>$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`TkdD$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`TkdJ$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`TkdP$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`TC$$If!vh#vF#vG#vF#vG#v F#v G#v F#vG:V lX  t֖O,5F5G5F5G5 F5 G5 F5G/ / / /  Bap֖yt-h`Tkd:W$$IfTlXN4z M!'f,168<AF LRQFFFFFFFGFFFFFFFGFFFFFFFGFFFFFG  t֖O<<<<44 lBap֖yt-h`Ti[Ci[Ci[Ci[Ci[Ci[Cj 666666666vvvvvvvvv666666>6666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ OJPJQJ_HmH nH sH tH R`R -cNormal $1$a$ CJKH_HaJmH nHsH tHDA`D Default Paragraph FontRi@R 0 Table Normal4 l4a (k ( 0No List L@L  0Header9r G$Pa$CJaJ66  0 Header CharCJaJB @B  0Footer9r G$a$CJaJ6!6  0 Footer CharCJaJPK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭V$ !)O^rC$y@/yH*񄴽)޵߻UDb`}"qۋJחX^)I`nEp)liV[]1M<OP6r=zgbIguSebORD۫qu gZo~ٺlAplxpT0+[}`jzAV2Fi@qv֬5\|ʜ̭NleXdsjcs7f W+Ն7`g ȘJj|h(KD- dXiJ؇(x$( :;˹! 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