Research Paper Volume 12, Issue 11 pp 10594—10613
Coagulation factor 2 thrombin receptor promotes malignancy in glioma under SOX2 regulation
- 1 Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, PR. China
- 2 Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, PR. China
- 3 Department of Operating Theatre, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, PR. China
Received: December 17, 2019 Accepted: April 17, 2020 Published: June 7, 2020
https://doi.org/10.18632/aging.103281How to Cite
Copyright © 2020 Gao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abbreviations
F2R: Coagulation factor 2 thrombin receptor; SOX2: SRY-box 2; GSEA: Gene Set Enrichment Analysis; GBM: Glioblastoma multiforme; TCGA: The Cancer Genome Atlas; Sh-RNA: Short hairpin RNA; ChIP: Chromatin immunoprecipitation; EMT: epithelial-mesenchymal transition; GBM: Glioblastoma multiforme; LGG: Brain Lower Grade Glioma.