ࡱ> >@  !"#$%&'()*+,-./0123456789:;<=Root Entry F {`Z?WorkbookvSummaryInformation(DocumentSummaryInformation8 \p TO }v Ba==a508X@"1Arial1Arial1Arial1Arial1Arial1.Times New Roman1.Times New Roman1.Times New Roman1Arial1[SO1JI{~1 h6JI{~ Light1,6JI{~16JI{~16JI{~1JI{~1JArial1JI{~1JI{~14JI{~1 JI{~1JI{~1 JI{~14JI{~1 JI{~1<JI{~1?JI{~1>JI{~1JArial""#,##0;""\-#,##0""#,##0;[Red]""\-#,##0""#,##0.00;""\-#,##0.00#""#,##0.00;[Red]""\-#,##0.007*2_ ""* #,##0_ ;_ ""* \-#,##0_ ;_ ""* "-"_ ;_ @_ .))_ * #,##0_ ;_ * \-#,##0_ ;_ * "-"_ ;_ @_ ?,:_ ""* #,##0.00_ ;_ ""* \-#,##0.00_ ;_ ""* "-"??_ ;_ @_ 6+1_ * #,##0.00_ ;_ * \-#,##0.00_ ;_ * "-"??_ ;_ @_ \$#,##0_);\(\$#,##0\)\$#,##0_);[Red]\(\$#,##0\) \$#,##0.00_);\(\$#,##0.00\)% \$#,##0.00_);[Red]\(\$#,##0.00\)"$"#,##0_);\("$"#,##0\)!"$"#,##0_);[Red]\("$"#,##0\)""$"#,##0.00_);\("$"#,##0.00\)'""$"#,##0.00_);[Red]\("$"#,##0.00\)72_("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_).)_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)?:_("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_)61_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_) 0.000 0.000E+00"Yes";"Yes";"No""True";"True";"False""On";"On";"Off"],[$ -2]\ #,##0.00_);[Red]\([$ -2]\ #,##0.00\) 0.000000_  0.00000_  0.0000_  0.000_                                                        P  P          a>       ff    `                           !  !   ! ! 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Homo sapiens (human)ARHGEF26//BCAR1//CAV1//CAV2//CLTB//CRK//FN1//ITGA5//MET//PIK3CA//PIK3R1//PIK3R2//SEPT11//SEPT2//SEPT6//SHC1//SHC2//SRC//WASF1//WASLhsa05205.Proteoglycans in cancer - Homo sapiens (human) AKT3//ANK3//CAMK2B//CAMK2D//CAV1//CAV2//CDKN1A//EGFR//FGF1//FGFR1//FLNA//FLNB//FN1//FRS2//FZD4//FZD7//FZD8//FZD9//GPC1//HPSE//HSPG2//IQGAP1//ITGA5//ITPR3//KDR//MAPK12//MET//PIK3CA//PIK3R1//PIK3R2//PPP1R12B//PTCH1//ROCK2//SDC2//SLC9A1//SRC//THBS1//TIMP3//VEGFA//WNT5Bhsa041511PI3K-Akt signaling pathway - Homo sapiens (human)qAKT3//BCL2L1//CDK6//CDKN1A//CHRM2//COL11A1//COL11A2//COL1A1//COL2A1//COL5A1//COL6A3//COL6A6//CREB3//EFNA1//EGF//EGFR//EPHA2//FGF1//FGFR1//FGFR2//FLT1//FN1//G6PC2//GHR//GNG4//IBSP//IRS1//ITGA1//ITGA11//ITGA3//ITGA5//ITGA6//ITGB8//KDR//LAMA4//LAMB2//MET//NGFR//OSMR//PHLPP2//PIK3CA//PIK3R1//PIK3R2//PPP2R3A//PRL//RPTOR//SPP1//THBS1//THBS2//THEM4//TNC//VEGFA//YWHAG//YWHAHhsa04360$Axon guidance - Homo sapiens (human)ABLIM2//ABLIM3//DPYSL2//EFNA1//EPHA1//EPHA2//EPHA3//MET//NCK2//NTNG1//PLXNA2//PLXNA3//PLXNB2//PPP3CA//RHOD//ROCK2//SEMA3B//SEMA3C//SEMA3E//SEMA4C//SEMA5A//SEMA6A//SEMA6D//SLIT2//UNC5Bhsa04390AXIN1//BMP2//BMP5//BMP8B//CSNK1E//CTGF//DLG1//DLG2//FGF1//FRMD6//FZD4//FZD7//FZD8//FZD9//GDF5//INADL//LIMD1//NF2//SERPINE1//SNAI2//TEAD1//TGFB3//TGFBR2//WNT5B//WTIP//YAP1//YWHAG//YWHAHhsa054108Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)sACE//AGT//CACNA2D2//CACNA2D3//ITGA1//ITGA11//ITGA3//ITGA5//ITGA6//ITGB8//MYL3//SGCD//TGFB3//TNNC1//TNNT2//TPM1//TTNhsa04012-ErbB signaling pathway - Homo sapiens (human)mABL2//AKT3//CAMK2B//CAMK2D//CDKN1A//CRK//EGF//EGFR//NCK2//NRG1//PIK3CA//PIK3R1//PIK3R2//SHC1//SHC2//SRC//TGFAhsa05214Glioma - Homo sapiens (human)WAKT3//CAMK2B//CAMK2D//CDK6//CDKN1A//EGF//EGFR//PIK3CA//PIK3R1//PIK3R2//SHC1//SHC2//TGFAhsa048107Regulation of actin cytoskeleton - Homo sapiens (human)BAIAP2//BCAR1//CHRM2//CRK//DIAPH3//EGF//EGFR//FGF1//FGFR1//FGFR2//FN1//GNA12//GSN//IQGAP1//ITGA1//ITGA11//ITGA3//ITGA5//ITGA6//ITGB8//MYL5//PIK3CA//PIK3R1//PIK3R2//PIP5K1A//PPP1R12B//ROCK2//SLC9A1//SRC//WASF1//WASLhsa04978)Mineral absorption - Homo sapiens (human)FCLCN2//CYBRD1//MT1B//MT1E//MT1G//MT1M//MT1X//MT2A//SLC46A1//TRPM6//VDRhsa05412MArrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)aCACNA2D2//CACNA2D3//CDH2//DSC2//DSG2//GJA1//ITGA1//ITGA11//ITGA3//ITGA5//ITGA6//ITGB8//PKP2//SGCDhsa04066.HIF-1 signaling pathway - Homo sapiens (human)AKT3//CAMK2B//CAMK2D//CDKN1A//EGF//EGFR//EGLN1//EGLN3//ENO2//FLT1//LDHA//PDHA1//PIK3CA//PIK3R1//PIK3R2//SERPINE1//SLC2A1//VEGFAhsa05414-Dilated cardiomyopathy - Homo sapiens (human)pADCY8//CACNA2D2//CACNA2D3//ITGA1//ITGA11//ITGA3//ITGA5//ITGA6//ITGB8//MYL3//SGCD//TGFB3//TNNC1//TNNT2//TPM1//TTNhsa05200)Pathways in cancer - Homo sapiens (human)AKT3//AXIN1//BCL2L1//BCR//BMP2//CDK6//CDKN1A//CDKN2B//CRK//DAPK2//EGF//EGFR//EGLN1//EGLN3//FGF1//FGFR1//FGFR2//FN1//FZD4//FZD7//FZD8//FZD9//GLI1//HHIP//ITGA3//ITGA6//LAMA4//LAMB2//MET//MITF//PIK3CA//PIK3R1//PIK3R2//PPARG//PTCH1//SLC2A1//TGFA//TGFB3//TGFBR2//VEGFA//WNT5B//ZBTB16hsa047225Neurotrophin signaling pathway - Homo sapiens (human)AKT3//CAMK2B//CAMK2D//CRK//FRS2//IRAK1//IRS1//KIDINS220//MAPK12//MAPK7//NGFR//NGFRAP1//NTRK2//NTRK3//PIK3CA//PIK3R1//PIK3R2//SHC1//SHC2hsa05220/Chronic myeloid leukemia - Homo sapiens (human)WAKT3//BCL2L1//BCR//CDK6//CDKN1A//CRK//PIK3CA//PIK3R1//PIK3R2//SHC1//SHC2//TGFB3//TGFBR2hsa04144"Endocytosis - Homo sapiens (human)AGAP3//AP2B1//ARFGAP1//ASAP2//CAV1//CAV2//CLTB//EGF//EGFR//EHD2//EHD4//EPN1//FGFR2//FLT1//IQSEC1//IQSEC2//KDR//MET//NEDD4L//PIP5K1A//PSD2//RAB11FIP3//RAB11FIP5//SH3GL1//SRC//TGFB3//TGFBR2//ZFYVE9hsa05211+Renal cell carcinoma - Homo sapiens (human)PAKT3//CRK//EGLN1//EGLN3//MET//PIK3CA//PIK3R1//PIK3R2//SLC2A1//TGFA//TGFB3//VEGFAhsa05212(Pancreatic cancer - Homo sapiens (human)QAKT3//BCL2L1//CDK6//EGF//EGFR//PIK3CA//PIK3R1//PIK3R2//TGFA//TGFB3//TGFBR2//VEGFAhsa04310AXIN1//CAMK2B//CAMK2D//CSNK1A1//CSNK1E//CXXC4//DAAM2//FZD4//FZD7//FZD8//FZD9//LRP5//NKD2//PLCB1//PPP3CA//PRICKLE2//ROCK2//TBL1X//WIF1//WNT5Bhsa00600.Sphingolipid metabolism - Homo sapiens (human)@ACER1//CERS1//CERS4//CERS6//GAL3ST1//SGMS2//SMPD1//SMPD4//SPTLC3hsa05218Melanoma - Homo sapiens (human)MAKT3//CDK6//CDKN1A//EGF//EGFR//FGF1//FGFR1//MET//MITF//PIK3CA//PIK3R1//PIK3R2hsa05217+Basal cell carcinoma - Homo sapiens (human)=AXIN1//BMP2//FZD4//FZD7//FZD8//FZD9//GLI1//HHIP//PTCH1//WNT5Bhsa043501TGF-beta signaling pathway - Homo sapiens (human)SBMP2//BMP5//BMP8B//CDKN2B//FST//GDF5//ID4//NOG//SMAD9//TGFB3//TGFBR2//THBS1//ZFYVE9hsa00780(Biotin metabolism - Homo sapiens (human) BTD//HLCShsa04340>BMP2//CSNK1A1//CSNK1E//CSNK1G3//GLI1//HHIP//LRP2//PTCH1//WNT5Bhsa04115,p53 signaling pathway - Homo sapiens (human)SCCNG1//CDK6//CDKN1A//GADD45A//GADD45B//IGFBP3//RRM2//SERPINE1//SESN3//THBS1//TP53I3hsa04261=Adrenergic signaling in cardiomyocytes - Homo sapiens (human)ADCY8//ADRA1A//AKT3//CACNA2D2//CACNA2D3//CAMK2B//CAMK2D//CREB3//MAPK12//MYL3//PIK3CA//PIK3R1//PIK3R2//PLCB1//PPP2R3A//SCN1B//SLC9A1//TNNC1//TNNT2//TPM1hsa05222-Small cell lung cancer - Homo sapiens (human)YAKT3//BCL2L1//CDK6//CDKN2B//FHIT//FN1//ITGA3//ITGA6//LAMA4//LAMB2//PIK3CA//PIK3R1//PIK3R2hsa04370-VEGF signaling pathway - Homo sapiens (human)CAKT3//KDR//MAPK12//PIK3CA//PIK3R1//PIK3R2//PPP3CA//SHC2//SRC//VEGFAhsa049747Protein digestion and absorption - Homo sapiens (human)gCOL11A1//COL11A2//COL13A1//COL1A1//COL2A1//COL5A1//COL6A3//COL6A6//COL9A1//COL9A2//COL9A3//CPA2//SLC8A3hsa00230(Purine metabolism - Homo sapiens (human)ADCY8//ENPP1//ENTPD6//FHIT//GDA//IMPDH1//NME6//NPR2//NT5C1A//NT5E//PAPSS2//PDE2A//PDE3A//PDE3B//PDE5A//PDE6B//PFAS//PGM1//POLD2//POLR3C//POLR3H//RRM2hsa040200Calcium signaling pathway - Homo sapiens (human)ADCY8//ADRA1A//CACNA1G//CAMK2B//CAMK2D//CHRM2//DRD5//EGFR//GNA11//HTR4//ITPKC//ITPR3//ORAI2//PHKA2//PLCB1//PLCD3//PPP3CA//RYR1//SLC25A4//SLC8A3//TACR1//TNNC1//VDAC1hsa04540#Gap junction - Homo sapiens (human)UADCY8//EGF//EGFR//GJA1//GNA11//ITPR3//MAPK7//PLCB1//SRC//TUBA8//TUBB2A//TUBB3//TUBB4Ahsa04070<Phosphatidylinositol signaling system - Homo sapiens (human)VDGKG//IMPA1//INPP5A//IPPK//ITPKC//ITPR3//PIK3CA//PIK3R1//PIK3R2//PIP5K1A//PLCB1//PLCD3hsa005127Mucin type O-Glycan biosynthesis - Homo sapiens (human)2C1GALT1//GALNT10//GALNT2//GALNT3//ST3GAL1//WBSCR17Number.Hippo signaling pathway - Homo sapiens (human) 71Hedgehog signaling pathway - Homo sapiens (human) 7,Wnt signaling pathway - Homo sapiens (human) 7 Fisher-Pvalue 7Enrichment score 7 Pathway name 7Different gene count in pathway 7PTable S4 The down-regulated mRNAs related pathways in no dural penetration group 71 k3e509*: 3=- > ^AX_CYD9F3lGf)I#KzLmNgccJ PK![Content_Types].xmlj0Eжr(΢Iw},-j4 wP-t#bΙ{UTU^hd}㨫)*1P' ^W0)T9<l#$yi};~@(Hu* Dנz/0ǰ $ X3aZ,D0j~3߶b~i>3\`?/[G\!-Rk.sԻ..a濭?PK!֧6 _rels/.relsj0 }Q%v/C/}(h"O = C?hv=Ʌ%[xp{۵_Pѣ<1H0ORBdJE4b$q_6LR7`0̞O,En7Lib/SeеPK!kytheme/theme/themeManager.xml M @}w7c(EbˮCAǠҟ7՛K Y, e.|,H,lxɴIsQ}#Ր ֵ+!,^$j=GW)E+& 8PK!e\{theme/theme/theme1.xmlYKo7X콱dḉ_9RK\݂T(P -r)PCQ4@4h/u MD.)QmvrrypfY#c.~Zp<`C ^o'$7)͏?6d#|,6PL6VVýpɃ!G'7+Rm%B$E`4"7?ߜP0Kwl jp\V1-ʽcD>~(}"!F/?e Ȅ\"kmL.WMsJRkNSr}iꋭڪdXtnke o_[yYx JW-נ_]WͶ_R|m_/m+uKtZ[kvCF8v}5S^R&F,j-BGo@)$4#4bn!Jx$2602K,zbI"Qh}=}ϦvKnŁ)/߽}ujz/L>R7_xٗo~|оQ߄HO, >?D/DĒ@!vOu}<ޚYvC>aNY=hqg([F{8pwcw& (qlrXXzcBgxMD!鑾UH /Sj+6{&]񱍄Q=L0B"]$C)SuXINF6K2vE6B%.lġTDwȤ 'D]CP4 ~"iT3\̪v,vYI`.!޽O4Ybżpv]uٵc,'E%*.s3Eq2u3cN*= '0A8r @QK]Zuʭr %s2MQ@Q0=#nAJ!8FC[FkH&-l4n):04vFeFCXdjns˲gjZY6S\M+>LWJv:r9J1ғ}n-=JrJ'7Y۰%Ώ~6,\8vCOWJ0z٩[$c\V'igHj'M2E \^{ҙJa F"LI'eH=JƚCoU ֹu9Hd<4nH)W8j񋃕$@ Ī 4PN9$5+'SF$]C:Iby TWٞ!FHFT5juӼk>,R3Hf1¬ bMjbhfO{rg\77']u ckEVڽcv&a~mv.nyp u~ZXJi2G@mr'T J D]=䴡E7PK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 +_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!e\{theme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK]   (xabqu  dMbP?_*+%&?'?(?)?M6Microsoft XPS Document WriterX 4dXXA4DINU"L r SMTJMicrosoft XPS Document WriterInputBinFORMSOURCERESDLLUniresDLLInterleavingOFFImageTypeJPEGMedOrientationPORTRAITCollateOFFResolutionOption1PaperSizeLETTERColorMode24bpp MXDW"dXX??&U} G}  } m"} IB} $F} $B} (,N,L      My OPO Iq I Iw Ju Kx Jv I~ H? @ @D:@[P>~ EF@CйD@ @~ H@ @ @A0>~ E8@Cu$@ @~ H@ @ @ AyDVg^>~ E4@C@ @ ~ H@ @ @ A=r>~ ED@CB@ @ ~ H@ @ @A(o>~ EK@C0.@ @~ H@ @ @A(?~ E9@CRE:@ @~ H@ @ @rA%V/H ?~ E<@CUD @ @~ H @ @ @ C 4O`O?~ E1@ C؞Y&@ @~ H"@ @ @ Cg|{T?~ E1@ Cr]4@ @~ H$@ @ @ CU+6n?~ E*@ C!w(w@ @~ H&@ @ @  Cn?~ E?@ C^*6ud@ @!~ H(@ @" @# C jp?~ E&@ CR%-@ @$~ H*@ @% @&CLБ"Sr?~ E,@C/.Ui@ @'~ H,@ @( @)C s?~ E2@CGȰ@ @*~ H.@ @+ @,C90s?~ E0@CӞs@ @-~ H0@ @. @/CX}?~ EE@C>(@ @0~ H1@ @1 @2CT'_a?~ E3@C<,Ԛ@ @3~ H2@ @4 @5C<3Ä?~ E*@Cpq? @6~ H3@ @7 @8C.Z>g?~ E<@C0k? @9~ H4@ @: @;CS?~ E(@Cf,? @<~ H5@ @= @>CS?~ E(@Cf,? @?~ H6@ @@ @tC\メ?~ E4@C#^? @A~ H7@ @B @CCl^@?~ E@CMN S? @P~ H<@ @Q @sCM?E"@Cb@ @R~ H=@ @S @TCbr?~ E&@CK)U? @U~ H>@ @V @WC% N?~ E4@C1%? @XDblbjjjjjjjjjjjjjjjjjjjjjjjjjjj`j !"#$%&'~ H?@ @Y @Z Cvr~q?~ E*@ Cc AJ? @[~ !H@@ !@\ !@]!Cp% G?~ !E$@!CϤM=? !@^~ "H@@ "@_ "@`"Cu(\찥?~ "E*@"CC? "@a~ #HA@ #@b #@c#C6 D$?~ #E6@#C /? #@d~ $HA@ $@e $@f$CsV¿?~ $E7@$C ? $@g~ %HB@ %@h %@i%C >u?~ %E*@%Chl? %@j~ &HB@ &@k &@l&C%r ?~ &E(@&C:ǀ? &@m~ 'HC@ '@n '@o'CblX?~ 'E@'C8d? '@pjjjjjjj>@   7ggD Oh+'0P(0 <HLQ@5 ՜.+,0HP X`hp x  Pathway analysis-down  F#Microsoft Office Excel 2003 Biff8Excel.Sheet.89qCompObjo