COVID-19 Review Volume 12, Issue 13 pp 13791—13802
Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage
- 1 The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China
- 2 Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China
- 3 Department of Neurology, Clinical Medical College of Yangzhou, Dalian Medical University, Yangzhou 225001, Jiangsu, China
Received: March 14, 2020 Accepted: June 5, 2020 Published: July 7, 2020
https://doi.org/10.18632/aging.103511How to Cite
Copyright © 2020 Dong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Intracerebral hemorrhage (ICH) is associated with old age and underlying conditions such as hypertension and diabetes. ICH patients are vulnerable to SARS-CoV-2 infection and develop serious complications as a result of infection. The pathophysiology of ICH patients with SARS-CoV-2 infection includes viral invasion, dysfunction of the ACE2–Ang (1–7)–MasR and ACE–Ang II–AT1R axes, overactive immune response, cytokine storm, and excessive oxidative stress. These patients have high morbidity and mortality due to hyaline membrane formation, respiratory failure, neurologic deficits, and multiple organ failure.