Supplementary Table 2. Methylation-driven genes among the DEGs. ,,,,
,,,,
,,,,
gene,HR,Wald value,95%CI,p-value
ABCB1,0.986892091,-0.296823653,"0.99 [0.90, 1.08]",0.766601146
ACTL10,0.963119788,-0.418475834,"0.96 [0.81, 1.15]",0.675599251
AFAP1.AS1,1.076449282,2.683713242,"1.08 [1.02, 1.14]",0.007280953
AKR1E2,1.02737876,0.525410287,"1.03 [0.93, 1.14]",0.599298004
ALX1,1.037400649,0.765327567,"1.04 [0.94, 1.14]",0.444076512
ANKRD18B,1.027807063,0.637956934,"1.03 [0.94, 1.12]",0.523501715
ANO5,1.014233211,0.353084963,"1.01 [0.94, 1.10]",0.724024746
APOA2,0.968687385,-0.754606868,"0.97 [0.89, 1.05]",0.450484901
AQP5,1.011909337,0.350650848,"1.01 [0.95, 1.08]",0.725850304
AREG,0.934499685,-1.330947862,"0.93 [0.85, 1.03]",0.183206167
ARL14,0.931984101,-1.207821503,"0.93 [0.83, 1.04]",0.227115929
ARL4D,1.099739307,1.356492747,"1.10 [0.96, 1.26]",0.174942441
AXIN2,0.894566262,-2.012012535,"0.89 [0.80, 1.00]",0.044218616
AZGP1,0.985743035,-0.274698013,"0.99 [0.89, 1.09]",0.783548258
B3GNT7,0.948757847,-1.23027535,"0.95 [0.87, 1.03]",0.218594012
BEX4,1.05021684,0.833352874,"1.05 [0.94, 1.18]",0.404645745
BHLHA9,1.00017349,0.003464365,"1.00 [0.91, 1.10]",0.997235842
BMP3,0.96386988,-0.990097612,"0.96 [0.90, 1.04]",0.322126411
BRINP3,0.960327287,-0.984687896,"0.96 [0.89, 1.04]",0.3247774
C5orf38,0.961430884,-1.268701982,"0.96 [0.90, 1.02]",0.204547375
CACNG4,1.040444134,1.351011957,"1.04 [0.98, 1.10]",0.176691602
CALCA,0.993235571,-0.19189321,"0.99 [0.93, 1.06]",0.847825857
CCDC169,1.033540961,0.649573275,"1.03 [0.94, 1.14]",0.515967901
CEL,0.996488073,-0.120574074,"1.00 [0.94, 1.06]",0.904028405
CES3,0.978380271,-0.426896936,"0.98 [0.88, 1.08]",0.669454397
CGREF1,1.004438509,0.07050747,"1.00 [0.89, 1.14]",0.943789755
CHST4,1.008074427,0.272788466,"1.01 [0.95, 1.07]",0.785015826
CIDEB,1.035536947,0.580278291,"1.04 [0.92, 1.17]",0.561726965
CILP2,1.127349928,2.62602888,"1.13 [1.03, 1.23]",0.008638749
CKMT2,0.95583053,-1.374941236,"0.96 [0.90, 1.02]",0.169149664
CLDN1,1.053413634,0.786235154,"1.05 [0.93, 1.20]",0.431729735
CLDN10,0.97490689,-0.654629321,"0.97 [0.90, 1.05]",0.512706441
CMBL,0.947125775,-0.932709003,"0.95 [0.84, 1.06]",0.350970235
CPNE8,0.965053624,-0.591146408,"0.97 [0.86, 1.09]",0.554422327
CSAG1,1.042651478,1.232530752,"1.04 [0.98, 1.11]",0.217750886
CT83,1.012029323,0.203244033,"1.01 [0.90, 1.14]",0.838944297
CTAG2,1.001354051,0.024975535,"1.00 [0.90, 1.11]",0.980074478
CWH43,0.960237152,-1.265600858,"0.96 [0.90, 1.02]",0.205656019
CYP24A1,0.957263347,-1.034481618,"0.96 [0.88, 1.04]",0.300911066
CYP2B7P,1.020338119,0.362114106,"1.02 [0.91, 1.14]",0.717266763
DAW1,1.050384981,0.686537882,"1.05 [0.91, 1.21]",0.492373985
DKK1,0.988134282,-0.320843878,"0.99 [0.92, 1.06]",0.748328706
DLX6,0.954746398,-1.29961102,"0.95 [0.89, 1.02]",0.193734321
DMRTA1,1.019597693,0.350313239,"1.02 [0.91, 1.14]",0.726103631
DNAH14,0.965129982,-0.671863149,"0.97 [0.87, 1.07]",0.501670822
DSC3,0.989730616,-0.331267363,"0.99 [0.93, 1.05]",0.740442541
EDNRA,1.006836376,0.11046999,"1.01 [0.89, 1.14]",0.912036649
ELF5,1.043126888,1.567682228,"1.04 [0.99, 1.10]",0.116955311
EPHA7,0.979824095,-0.437120153,"0.98 [0.89, 1.07]",0.662024212
EPHX3,1.127226382,2.050980672,"1.13 [1.01, 1.26]",0.040268829
EPHX4,0.876510923,-2.250390344,"0.88 [0.78, 0.98]",0.024424177
ERVMER34.1,1.050485474,1.088218306,"1.05 [0.96, 1.15]",0.276498745
EVA1A,0.942040528,-1.00011244,"0.94 [0.84, 1.06]",0.317256097
FABP1,1.008306654,0.2497257,"1.01 [0.94, 1.08]",0.802799482
FADS6,1.017316075,0.476447789,"1.02 [0.95, 1.09]",0.633755395
FAM181B,1.002171581,0.032552764,"1.00 [0.88, 1.14]",0.974031239
FAM218A,0.980730593,-0.30317199,"0.98 [0.86, 1.11]",0.761758794
FAM83C,0.997687641,-0.050160837,"1.00 [0.91, 1.09]",0.95999422
FGF20,0.997855137,-0.061132018,"1.00 [0.93, 1.07]",0.95125407
FIRRE,1.015955349,0.403602009,"1.02 [0.94, 1.10]",0.686505408
FOXG1,1.037136493,0.879241065,"1.04 [0.96, 1.12]",0.379270583
FOXQ1,1.096728323,1.603656145,"1.10 [0.98, 1.23]",0.108789868
FZD10,0.954843386,-1.371182633,"0.95 [0.89, 1.02]",0.170318031
GALNT16,1.025631472,0.494072945,"1.03 [0.93, 1.13]",0.621254664
GFRA3,1.028570035,0.533077541,"1.03 [0.93, 1.14]",0.593979905
GHR,1.03026323,0.587650506,"1.03 [0.93, 1.14]",0.556766903
GNG4,1.039504867,1.199116103,"1.04 [0.98, 1.11]",0.230482804
GPR143,0.963114506,-1.009547734,"0.96 [0.90, 1.04]",0.312712021
GREB1L,1.001005531,0.026683697,"1.00 [0.93, 1.08]",0.978712016
HABP2,1.013984807,0.422578521,"1.01 [0.95, 1.08]",0.6726028
HBQ1,1.049604453,0.889495689,"1.05 [0.94, 1.17]",0.373736739
HCAR1,1.004188881,0.121131794,"1.00 [0.94, 1.07]",0.903586646
HHLA2,0.962245914,-0.816614967,"0.96 [0.88, 1.06]",0.414148499
HIST3H2A,1.04689753,0.51674051,"1.05 [0.88, 1.25]",0.605337313
HYDIN,0.982144871,-0.331396577,"0.98 [0.88, 1.09]",0.74034495
IFITM1,0.925408234,-1.047227757,"0.93 [0.80, 1.07]",0.294994546
INA,1.02888176,0.563105697,"1.03 [0.93, 1.14]",0.573362912
IZUMO2,0.913962584,-2.113556136,"0.91 [0.84, 0.99]",0.034553196
KCNA3,0.941621525,-1.118260267,"0.94 [0.85, 1.05]",0.263455851
KHDRBS2,1.074775816,0.778948985,"1.07 [0.90, 1.29]",0.436009766
KLHL34,0.988973743,-0.275626807,"0.99 [0.91, 1.07]",0.782834718
KLRG2,1.051217539,1.361097894,"1.05 [0.98, 1.13]",0.173482755
KRT20,0.972665165,-0.612006244,"0.97 [0.89, 1.06]",0.540533626
KRT40,0.970655083,-0.911581735,"0.97 [0.91, 1.03]",0.361988941
KRTAP5.4,0.980239907,-0.30963347,"0.98 [0.86, 1.11]",0.756839701
LAPTM4B,1.002908624,0.042696631,"1.00 [0.88, 1.15]",0.965943365
LGALS2,0.923526205,-1.602416821,"0.92 [0.84, 1.02]",0.109063468
LINC00346,1.011527949,0.16669154,"1.01 [0.88, 1.16]",0.867612763
LINC00885,1.037395886,0.57629074,"1.04 [0.92, 1.18]",0.564418681
LINC00939,0.962998306,-0.709522375,"0.96 [0.87, 1.07]",0.478000371
LINC01356,1.079740326,1.153268326,"1.08 [0.95, 1.23]",0.248800266
LRFN5,0.997581406,-0.043269325,"1.00 [0.89, 1.11]",0.965486843
LY6E,1.146225224,1.995365808,"1.15 [1.00, 1.31]",0.046002997
LY6G6D,0.984814977,-0.611924642,"0.98 [0.94, 1.03]",0.540587617
MAGEA1,1.115697683,2.710899715,"1.12 [1.03, 1.21]",0.006710092
MAGEA4,1.038772465,1.049977993,"1.04 [0.97, 1.12]",0.293728231
MAGEB2,1.004816696,0.103597196,"1.00 [0.92, 1.10]",0.917489013
MEP1A,0.953481937,-1.152926686,"0.95 [0.88, 1.03]",0.248940478
MIA,1.022518989,0.529497651,"1.02 [0.94, 1.11]",0.596460273
MIOX,1.116950808,2.194293487,"1.12 [1.01, 1.23]",0.028214317
MIR181A2HG,1.092332967,1.391319166,"1.09 [0.96, 1.24]",0.164128664
MSX2,0.963127704,-0.888427677,"0.96 [0.89, 1.05]",0.374310743
MT1E,1.004715846,0.098798512,"1.00 [0.92, 1.10]",0.92129825
MYBL2,1.034554981,0.392368282,"1.03 [0.87, 1.23]",0.694786118
NAP1L2,1.045395744,0.854616756,"1.05 [0.94, 1.16]",0.392763348
NAT2,0.892096405,-2.546004298,"0.89 [0.82, 0.97]",0.010896385
NEFH,1.027525231,0.432815579,"1.03 [0.91, 1.16]",0.665148755
NEUROG2,0.99387254,-0.158341225,"0.99 [0.92, 1.07]",0.874187925
NMU,1.033367474,0.77103386,"1.03 [0.95, 1.12]",0.440686862
NOVA1,1.101151951,2.052141287,"1.10 [1.00, 1.21]",0.040155933
NPY1R,0.996169987,-0.092110173,"1.00 [0.92, 1.08]",0.926610506
NT5DC4,1.058284687,1.033544737,"1.06 [0.95, 1.18]",0.301349046
NXPH3,1.055722181,1.181457895,"1.06 [0.96, 1.16]",0.23742087
PABPC5,1.038117712,0.599790536,"1.04 [0.92, 1.17]",0.548645841
PAH,0.9447057,-1.753728502,"0.94 [0.89, 1.01]",0.079477039
PCDH10,1.085705387,1.527709139,"1.09 [0.98, 1.21]",0.12658477
PCDH20,0.988260535,-0.220593406,"0.99 [0.89, 1.10]",0.825409036
PCP4L1,0.998263748,-0.034811999,"1.00 [0.91, 1.10]",0.972229652
PF4,0.941003005,-1.565555754,"0.94 [0.87, 1.02]",0.117452655
PGC,1.030133419,0.705427811,"1.03 [0.95, 1.12]",0.480544042
PHGDH,1.107734987,1.891034948,"1.11 [1.00, 1.23]",0.058619679
PIGR,0.974358061,-1.07623818,"0.97 [0.93, 1.02]",0.281820749
PLA2G3,0.963361615,-1.217358898,"0.96 [0.91, 1.02]",0.223467694
POU4F1,1.120215467,2.402765529,"1.12 [1.02, 1.23]",0.016271617
PPBP,0.994316897,-0.182253576,"0.99 [0.94, 1.06]",0.855383729
PPP1R14A,1.151078282,1.997033797,"1.15 [1.00, 1.32]",0.045821512
PRDM13,0.965198272,-0.805158509,"0.97 [0.89, 1.05]",0.420728216
PTF1A,0.986168169,-0.327793627,"0.99 [0.91, 1.07]",0.743067706
PTPRO,0.959782899,-0.960886687,"0.96 [0.88, 1.04]",0.336609145
RASSF10,0.958103745,-0.968063044,"0.96 [0.88, 1.04]",0.333012885
RBP1,0.917972301,-1.758840305,"0.92 [0.83, 1.01]",0.078604637
REG4,0.961195544,-1.754191006,"0.96 [0.92, 1.00]",0.079397784
REP15,0.897112782,-2.45928144,"0.90 [0.82, 0.98]",0.013921543
RHCG,1.040935544,0.953443218,"1.04 [0.96, 1.13]",0.340365553
RIC3,1.08906564,1.665237589,"1.09 [0.99, 1.20]",0.095865364
RIPPLY3,0.997596421,-0.060279209,"1.00 [0.92, 1.08]",0.95193326
RSPO4,1.084262585,2.121807155,"1.08 [1.01, 1.17]",0.033853936
SLC14A1,1.015434262,0.419272925,"1.02 [0.95, 1.09]",0.675016681
SLC22A31,1.05766024,1.451662052,"1.06 [0.98, 1.14]",0.146595596
SLC30A2,0.975792015,-0.7213286,"0.98 [0.91, 1.04]",0.470707365
SLC35D3,0.985864699,-0.407041556,"0.99 [0.92, 1.06]",0.683977467
SLC3A1,0.987201416,-0.274745254,"0.99 [0.90, 1.08]",0.783511961
SLC51B,0.948600664,-1.159526914,"0.95 [0.87, 1.04]",0.246241472
SLC5A6,0.985904705,-0.16027359,"0.99 [0.83, 1.17]",0.872665562
SLCO4C1,0.855951816,-2.908426774,"0.86 [0.77, 0.95]",0.003632522
SMOC1,0.984282256,-0.457938811,"0.98 [0.92, 1.05]",0.646996402
SNCA,1.036665667,0.6340178,"1.04 [0.93, 1.16]",0.526069205
SOX1,1.029405167,0.98133478,"1.03 [0.97, 1.09]",0.326427677
SOX14,1.003431327,0.105275772,"1.00 [0.94, 1.07]",0.916156987
SP5,1.007713707,0.151538754,"1.01 [0.91, 1.11]",0.879550742
SPAG17,0.9915274,-0.15671576,"0.99 [0.89, 1.10]",0.875468866
SPDYC,1.018106741,0.380673059,"1.02 [0.93, 1.12]",0.703445862
SRPX2,0.996766594,-0.061771366,"1.00 [0.90, 1.10]",0.950744907
SUSD5,1.118428101,2.14207495,"1.12 [1.01, 1.24]",0.032187451
SYNE4,0.979461811,-0.521606443,"0.98 [0.91, 1.06]",0.601944376
TBX18,0.963075369,-0.983333596,"0.96 [0.89, 1.04]",0.32544328
TBX20,0.943324791,-1.480570518,"0.94 [0.87, 1.02]",0.138721057
TCN1,0.975020009,-0.828371824,"0.98 [0.92, 1.04]",0.407459958
TGFBI,0.931120869,-1.068392814,"0.93 [0.82, 1.06]",0.285343357
TGIF2,0.976134147,-0.317011188,"0.98 [0.84, 1.13]",0.751235113
TMEM171,1.035501875,0.512460939,"1.04 [0.91, 1.18]",0.608328451
TMEM220,0.882368002,-1.865050065,"0.88 [0.77, 1.01]",0.062174387
TMEM37,0.961656586,-0.583130259,"0.96 [0.84, 1.10]",0.559805615
TMPRSS5,0.988825391,-0.245289395,"0.99 [0.90, 1.08]",0.806232362
TNNC2,1.013838112,0.366229477,"1.01 [0.94, 1.09]",0.714193849
TRIM29,1.014670545,0.260844976,"1.01 [0.91, 1.13]",0.794212059
TRIM58,1.050593014,1.203842507,"1.05 [0.97, 1.14]",0.228650457
TUSC8,0.978450886,-0.578433351,"0.98 [0.91, 1.05]",0.562971582
TWIST1,1.053438203,0.896639783,"1.05 [0.94, 1.18]",0.369911162
UCN3,0.924969698,-1.86771434,"0.92 [0.85, 1.00]",0.061801899
VENTX,1.036438358,0.941237808,"1.04 [0.96, 1.12]",0.346583005
VSIG2,0.96284054,-1.131194798,"0.96 [0.90, 1.03]",0.257973111
VSTM2B,0.984361723,-0.284751922,"0.98 [0.88, 1.10]",0.775834209
WASIR2,1.079861589,1.393492525,"1.08 [0.97, 1.20]",0.163470904
WDR17,1.017387158,0.352883594,"1.02 [0.92, 1.12]",0.724175711
WIF1,0.964837048,-1.26104709,"0.96 [0.91, 1.02]",0.207291882
ZNF135,1.001542692,0.024581287,"1.00 [0.89, 1.13]",0.980388946
ZNF280A,1.072464124,1.411955454,"1.07 [0.97, 1.18]",0.157963078
ZNF471,0.956411844,-0.89988159,"0.96 [0.87, 1.05]",0.368183268
ZNF556,1.108735562,2.893667963,"1.11 [1.03, 1.19]",0.003807706
ZNF677,1.01652552,0.258295224,"1.02 [0.90, 1.15]",0.796179072