ࡱ> [ R/bjbj  ;Npa!\pa!\ VV8<V!l...  $#%D!E.....!4T!.R . U }  7 m  j!0!u &X&} } & D.......!!...!....&.........V> : Supplementary Table 3. The expression of the claudin family of breast cancer (UALCAN database). ParametersCLDN1CLDN2CLDN3CLDN4CLDN5CLDN6mRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valueExpression000000000000Normal-0.650-0.556sig<1.0E-12sig2.9E-8sig<1.0E-12sig5.62E-04Primary tumor-0-0high0high0low0high0DNA methylation000000000000Normalsig2.07E-05sig3.55E-05-0.640sig1.62E-12sig1.67E-15sig1.62E-12Primary tumorhigh0low0-0low0high0high0ParametersCLDN7CLDN8CLDN9CLDN10CLDN11CLDN12mRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valueExpression000000000000Normalsig1.62E-12sig<1.0E-12sig1.21E-14-0.916sig1.62E-12-0.545Primary tumorhigh0low0high0-0low0-0DNA methylation000000000000Normalsig2.91E-07sig<1.0E-12sig1.62E-12sig<1.0E-12sig1.62E-12sig3.30E-03Primary tumorlow0low0high0high0high0*     " $ & ( * , . 0 2 4 ̴ww)h{'qh\B*CJOJQJ^JaJphh{'qh\CJaJh{'qh\CJaJo( h{'qh\CJOJQJ^JaJ/h{'qh\5B*CJOJQJ\^JaJph#hzh\5CJOJQJ^JaJ#hzh})5CJOJQJ^JaJho5CJOJQJ^JaJ.   " , < F V ` p z FfwFf  $$Ifa$$If xedHgdXux      & * 6 > P X f n Ffx $$Ifa$Ff$If $ ( , 0 4 8 < @ D H L P $IfFf $$Ifa$4 6 8 : < > @ B D F H J L N P R Z \ ` b x z | ~ @Bתתתת/h{'qh\5B*CJOJQJ\^JaJph)h{'qh\B*CJOJQJ^JaJph h{'qh\CJOJQJ^JaJh{'qh\CJaJh{'qh\CJaJo(CP R ` h z    & * . 2 : > H L V Ff $$Ifa$FfvV Z \ r ~    , 6 F P ` b x | Ff#'Ff#$IfFft $$Ifa$|  04@ $$Ifa$ $$Ifa$Ff+$If@B^hltxFf4$If $$Ifa$Ff$0( ((x(z())0)2)4)6)8):)<)>)@)B)D)F)H)J)L)N)P)R)T)V)X)Z)\)^)`)b)))**,*.*2*4*6*:*<*ةةة/h{'qh\5B*CJOJQJ\^JaJphU)h{'qh\B*CJOJQJ^JaJph h{'qh\CJOJQJ^JaJh{'qh\CJaJo(h{'qh\CJaJB &8@RZltFf= $$Ifa$Ff"9$If( (($(2(@(N(\(j(x(z(|((((((((((())FfeF$IfFf B $$Ifa$low0ParametersCLDN14CLDN15CLDN16CLDN17CLDN18CLDN19mRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valueExpression000000000000Normalsig<1.0E-12sig2.33E-10-0.614-0.101-0.980sig1.62E-12Primary tumorhigh0low0-0-0-0low0DNA methylation000000000000Normal-0.143sig<1.0E-12sig<1.0E-12sig1.11E-16sig1.62E-12sig1.62E-12Primary tumor-0high0low0low0low0high0ParametersCLDN20CLDN22CLDN23CLDN240000mRNAp-valuemRNAp-valuemRNAp-valuemRNAp-value0000Expression000000000000Normalsig1.70E-06NA0-0.551NA00000Primary tumorlow000-0000000DNA methylation000000000000Normalsig1.60E-09NA0sig1.38E-04NA00000Primary tumorlow000high0000000Note: high means high expression;  low means low expression.      ))0)4)8)<)@)D)H)L)P)T)X)\)`)b)p)x))))))))))FfQN$If $$Ifa$FfI)))) ***"*&***.*2*6*:*>*F*J*L*l*p*t*x*|*****FfOW$IfFfR $$Ifa$<*>*J*L*l*n*p*r*t*v*x*z*|*~*****************>+@+`+b+d+++++++++,,,,p,r,t,v,x,z,|,~,,,,,,,,,,,,,,ϷϷϷϷh{'qh\CJaJo(/h{'qh\5B*CJOJQJ\^JaJph h{'qh\CJOJQJ^JaJ)h{'qh\B*CJOJQJ^JaJphh{'qh\CJaJC************** ++$+,+>+@+\+`+d+n+r+z+~+FfM` $$Ifa$Ff[$If~+++++++++++++++,,,,,",,,<,F,V,`,p,Ff+i$IfFfd $$Ifa$p,t,x,|,,,,,,,,,,,,,,,,,,,,,,- -Ffwq $$Ifa$Ffl$If,,,,,,,,,,,,,,,,,,,,, --------- -"-$-&-(-P-R-T-V-X-\-^-`-b-d-f-h-j-l-n-p-r-t-v-x-z-------------ת/h{'qh\5B*CJOJQJ\^JaJph)h{'qh\B*CJOJQJ^JaJph h{'qh\CJOJQJ^JaJh{'qh\CJaJh{'qh\CJaJo(C -----"-&-(-D-L-P-T-X-\-`-d-h-l-p-t-x-z------FfuzFfu$If $$Ifa$---------------...".&.*...2.4.P.X.\.Ffs $$Ifa$Ff~$If--------------------... .".$.&.(.*.,...0.2.4.\.^.`.b.d.r.t.v.x.z.|.~........./////دد h{'qh\CJOJQJ^JaJ&h{'qh\5CJOJQJ\^JaJ)h{'qh\B*CJOJQJ^JaJph h{'qh\CJOJQJ^JaJh{'qh\CJaJo(h{'qh\CJaJ:\.`.d.n.r.v.z.~...../Ff $$Ifa$$If ///{$If~kd*$$IfedHT4::0:62 24aitHp yt})T///// /"/$/&/(/*/,/./0/2/4/FfG$Ifnkd$$IfedHT4:0:64aitHyt})T/2/4/6/8//B/D/H/J/P/R/h+jh+Uh\#h{'qh\<CJOJQJ^JaJh{'qh\<CJaJ 4/6/:/> xl151330dd9D[$\$" xl631330^$dd$d%d&d'd9DNOPQ[$\$a$5B*OJQJ\^Jph2 xl641330^$dd$d%d&d'd9DNOPQ[$\$a$B*OJQJ^JphB xl651330^$dd$d%d&d'd9DNOPQ[$\$a$B*CJOJQJ^JaJphR xl661330Xdd$d%d&d'd9DNOPQ[$\$b xl671330^$dd$d%d&d'd9DNOPQ[$\$a$r xl681330Xdd$d%d&d'd9DNOPQ[$\$#5B*CJOJQJ\^JaJph xl691330Xdd$d%d&d'd9DNOPQ[$\$5B*CJ\aJph xl701330Xdd$d%d&d'd9DNOPQ[$\$5OJQJ\^J xl711330Xdd$d%d&d'd9DNOPQ[$\$ xl721330Xdd$d%d&d'd9DNOPQ[$\$5CJ OJQJ\^JaJ VV U-Header'$ 9r &dG$Pa$CJaJB/B U- Header CharCJOJQJ^JaJ> > U-Footer 9r G$CJaJB/B U- Footer CharCJOJQJ^JaJ<0< }) List Bullet & Fm$PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭VvnB`2ǃ,!"E3p#9GQd; H xuv 0F[,F᚜K sO'3w #vfSVbsؠyX p5veuw 1z@ l,i!b I jZ2|9L$Z15xl.(zm${d:\@'23œln$^-@^i?D&|#td!6lġB"&63yy@t!HjpU*yeXry3~{s:FXI O5Y[Y!}S˪.7bd|n]671. tn/w/+[t6}PsںsL. 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