ࡱ> 57234[ ibjbj  ;pa!\pa!\3 &&&&&&&&&&&8^&T&|&&o.l.(.(.(.(.(b)b)b)-------$/2D-u&b)b)b)b)b)-&&.(.(4)."-"-"-b)*&.(&.(-"-b)-"-"-"-.(p *."-z-?.0o."-2*h2"-"-2&6-Db)b)"-b)b)b)b)b)--"-b)b)b)o.b)b)b)b)2b)b)b)b)b)b)b)b)b)> $: Supplementary Table 4. Relationship between the claudin family and the clinicopathologic parameters of breast cancer (bc-GenExMiner v4.3). ParametersCLDN1CLDN2CLDN3CLDN4CLDN5CLDN6CLDN7CLDN8CLDN9CLDN10CLDN11mRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valueAge (years)0000000000000000000000<51-0.4625sig0.0394sig0.0044-0.1405-0.5489-0.5362-0.2876sig0.0002-0.1005sigp<0.0001sigp<0.0001>51-0low0high0-0-0-0-0low0-0low0low0Nodal status0000000000000000000000Negative-0.2511sigp<0.0001sigp<0.0001sigp<0.0001-0.3916-0.2272sigp<0.0001-0.5567-0.2028sig0.0372-0.3526Postive-0low0high0high0-0-0high0-0-0low0-0ER (IHC)0000000000000000000000Negativesigp<0.0001-0.3477sig0.0203sigp<0.0001sigp<0.0001sigp<0.0001sigp<0.0001sigp<0.0001sigp<0.0001sigp<0.0001sigp<0.0001Postivelow0-0high0low0high0low0high0low0low0low0high0PR (IHC)0000000000000000000000Negativesigp<0.0001sig0.0378-0.3144sigp<0.0001sigp<0.0001sigp<0.0001sigp<0.0001sigp<0.0001sig0.0231sigp<0.0001sigp<0.0001Postivelow0low0-0low0high0low0high0low0low0low0high0HER2 (IHC)0000000000000000000000Negative-0.3027sig0.0021-0.1928sig0.0052sig0.0392-0.7519-0.9971-0.2008-0.2520-0.2221-0.8659Postive-0high0-0high0low0-0-0-0-0-0-0Triple-negtive status0000000000000000000000Notsigp<0.0001-0.3752sig0.0036-0.6682sigp<0.0001sigp<0.0001sigp<0.0001sigp<0.0001sig0.0024sigp<0.0001sigp<0.0001TNBChigh0-0low0-0low0high0low0high0high0high0low0Basal-like stasus0000000000000000000000Not sigp<0.0001sig0.0207sig0.0004sigp<0.0001sigp<0.0001sigp<0.0001sig0.0004sigp<0.0001sigp<0.0001sigp<0.0001sigp<0.0001Basal-likehigh0high0low0high0low0high0low0high0high0high0low0ParametersCLDN12CLDN14CLDN15CLDN16CLDN17CLDN18CLDN19CLDN20CLDN22CLDN23CLDN24mRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valuemRNAp-valueAge (years)0000000000000000000000<51-0.3270-0.1030-0.1954-0.6365-0.6353-0.8845sig0.0169-0.1391-0.8305sigp<0.0001-0.4403>51-0-0-0-0-0-0low0-0-0low0-0Nodal status000000k l              " $ & ( * , . 0 2 4 rf[f[f[f[f[f[f[f[f[f[f[f[f[hP hCJaJhP hCJaJo()hP hB*CJOJQJ^JaJph hP hP CJOJQJ^JaJ hP hCJOJQJ^JaJ/hP h5B*CJOJQJ\^JaJph hxPhCJOJQJ^JaJ)hu35B*CJOJQJ\^JaJph/hxPhP 5B*CJOJQJ\^JaJph#     " FfA $$Ifa$$If xed? gdP " * / 7 < D I Q V ^ c k l x       $ ( , 0 4 8 $IfFf$ $$Ifa$4 6 8 : < > @ B D F H J L N P R T V X Z D F              " $ & ( * , . 0 2 . 0 )hP hB*CJOJQJ^JaJph hP hP CJOJQJ^JaJhP hCJaJhP hCJaJo(L8 < @ D H L P T X Z b f t |  $IfFf $$Ifa$   * 2 D F N R V ^ b l p t x | $IfFf $$Ifa$       $ ( , 0 $IfFf $$Ifa$0 2 D H V ^ p x    . 0 @ Ff. $$Ifa$$IfFf&@ D H P T ^ b l p t x | $IfFf6 $$Ifa$   2:LP^ft$IfFf> $$Ifa$    DF "$&(*,.02468:<>@BDFHJLln$&(<>@BDFHJLNPRTVX)hP hB*CJOJQJ^JaJph hP hP CJOJQJ^JaJhP hCJaJhP hCJaJo(Lt|*2DFV^bfjtx$IfFfF $$Ifa$ "$IfFfjN $$Ifa$"&*.26:>BFJL^fx$IfFfUV $$Ifa$"*8@RZln~$IfFf@^ $$Ifa$ $(,048<@DHLPTX\`dhlp$IfFf+f $$Ifa$XZ\^`bdfhjlnprtvZ\  "$&(*,.02468:<>@BDFHJLNPRTVXZ\jl*,.BDFHJLNPRTVXZ\^`b)hP hB*CJOJQJ^JaJph hP hP CJOJQJ^JaJhP hCJaJhP hCJaJo(Lptv$(6:HLZ\Ffv$IfFfn $$Ifa$\lpt~ Ff} $$Ifa$$If "&*.26:>BFJNRVZ\dl~$IfFfׅ $$Ifa$ (6>PXjlv$IfFf $$Ifa$"&*.26:>BFJN$IfFf $$Ifa$NRVZ^bfjnrvz|"0$IfFf $$Ifa$bdfhjlnprtvxz|BD02468:<>@BDFHJLNPRTVXZ\^`bdfhjlnprtvxz|ת hP hCJOJQJ^JaJ/hP h5B*CJOJQJ\^JaJph)hP hB*CJOJQJ^JaJph hP hP CJOJQJ^JaJhP hCJaJhP hCJaJo(<08JRdl~ $$IfFf $$Ifa$$(26>BDZhv,6FFfʳ$IfFfn $$Ifa$FP`jz048<@DHLPT$IfFf $$Ifa$TX\`dhlptx| $$Ifa$Ff$If|~dfZZZZZ Z ZZZZZZZZZZ Z"Z$Z&Z(Z*Z,Z.Z0Z2Z4Z6Z8Z:ZZ@ZBZDZ0[2[[[[[[[[[[[[[[[[[[U)hP hB*CJOJQJ^JaJph hP hP CJOJQJ^JaJhP hCJaJhP hCJaJo(L&*8@RVdfnrvz~$IfFf $$Ifa$ZZ ZZZZZZ"Z&Z*Z.Z2Z$IfFfq $$Ifa$0000000000000000Negative-0.1347-0.0770sigp<0.0001-0.3031-0.2974-0.7703sigp<0.0001-0.5185-0.5187sig0.0219-0.0731Postive-0-0high0-0-0-0low0-0-0low0-0ER (IHC)0000000000000000000000Negativesigp<0.0001sig0.0008-0.3919sigp<0.0001sig0.0175-0.1727-0.2717-0.1714-0.2465sigp<0.0001sig0.0469Postivehigh0low0-0low0low0-0-0-0-0low0low0PR (IHC)0000000000000000000000Negativesigp<0.0001sig0.0018-0.4125sig0.0056-0.9336-0.3483-0.2160-0.1215sig0.0104sigp<0.0001sig0.0254Postivehigh0low0-0low0-0-0-0-0low0low0low0HER2 (IHC)0000000000000000000000Negativesigp<0.0001-0.0771-0.6903-0.0981-0.6518-0.4619-0.1268-0.6706-0.9876-0.2144-0.4370Postivelow0-0-0-0-0-0-0-0-0-0-0Triple-negtive status0000000000000000000000Notsigp<0.0001-0.0857-0.9696sigp<0.0001-0.5144-0.7404sig0.0123sigp<0.0001-0.1588sigp<0.0001-0.1096TNBClow0-0-0high0-0-0low0high0-0high0-0Basal-like stasus0000000000000000000000Not sigp<0.0001sig0.0033-0.3919sigp<0.0001-0.1993-0.9479sig0.0057-0.4828sig0.0436sigp<0.0001-0.0896Basal-likelow0high0-0high0-0-0low0-0high0high0-0Notes: All the data of the claudins family were based on bc-GenExMiner v4.3.  sig means the comparson between two groups was considered statistically significant . P<0.05 was considered statistically significant.  high means high expression;  low means low expression. Abbreviations: bc-GenExMiner, Breast cancer Gene-Expression Miner; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; PR, progesterone receptor; TNBC, triple-negative breast cancer.     2Z6Z:Z>ZBZDZVZZZhZlZzZZZZZZZZZZZZZZ[[["[ $$Ifa$Ff\$If"[0[2[B[F[J[N[R[\[`[d[h[l[p[t[x[[[[[[[[[[[[Ff2$IfFfG $$Ifa$[[[[[[[[[[[[[[[[[[\\\ \\\\(\0\B\Ff $$Ifa$$If[[[[[[[[[[[[[[[[[[[\\\\\ \ \\\\\\]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]^)hP hB*CJOJQJ^JaJph hP hP CJOJQJ^JaJhP hCJaJo(hP hCJaJMB\J\X\\\j\r\\\\\\\\\\\\\\]]]$].]2]:]>]B]$IfFf $$Ifa$B]F]N]R]Z]^]b]f]j]n]r]v]z]~]]]]]]]]]]]]]]]$IfFf $$Ifa$]]]]]]]]]]]]]]^^^^0^8^F^J^X^`^n^r^^^ $$Ifa$Ff$If^^^^^_______________________________________________``@aBanaparatavaza|a~aaaaaaaaaaaaaaahP hCJaJo()hP hB*CJOJQJ^JaJph hP hP CJOJQJ^JaJhP hCJaJM^^^^^^^^^^^^^___$_(_,_0_8_<_@_D_H_L_P_T_$IfFf $$Ifa$T_X_\_d_h_p_t_|_____________________$IfFf $$Ifa$_______` ``"`0`4`B`F`T`X`f`j`x`|```````` $$Ifa$Ff $If``````````aaa aaaaa a$a(a,a0a4a8ae)hP hB*CJOJQJ^JaJph hP hP CJOJQJ^JaJhP hCJaJhP hCJaJo(Laaaaabbb(b,b:b>bLbTbbbjb|bbbbbbbbbbbb$IfFfK@ $$Ifa$bbbbbbbbbcc cccc"c,c0c4c8c:c^cbcfcjcncrcvc$IfFf6H $$Ifa$vczc~ccccccccccccccccccccccd dd"d $$Ifa$Ff!P$If"d0d4dBdJdXd\djdrddddddddddddddddddee$IfFf X $$Ifa$e eeee"e&e0e4e8ee2i$IfFf_ $$Ifa$ >eJee&ghgg2i4i6i8i:ii@iBiDiritivixi|i~iiiiiiiҰҰҰҰҞ|tptptptp|hjhUh#hP hP <CJOJQJ^JaJhP h<CJaJ#hP h<CJOJQJ^JaJ hP hCJOJQJ^JaJ hP hCJOJQJ^JaJ)hP hB*CJOJQJ^JaJph/hP h5B*CJOJQJ\^JaJph2i4i6i{$If~kde$$Ifed? 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