ࡱ> ac`Y bjbj[[ ;`9 \9 \  >>>>>RRRR ^$R www       $r"(%>7 >wwwww7 >>L wN>>pw 4) b 0 f%"f%f%>wwwwwww7 7 www wwwwf%wwwwwwwww > : Supplementary Table 6. Anti-neoplastic drugs predicted by DGIdb. GeneDrugInteraction Type & DirectionalitySourcesPMIDsQuery ScoreInteraction ScoreNEK2PAZOPANIBn/aDTC-0.190.07NEK2PALBOCICLIBn/aDTC-0.090.07NEK2FOSTAMATINIBinhibitorDrugBank265165870.060.02TOP2AFINAFLOXACINinhibitorDrugBank258088318.711.17TOP2AVALRUBICINinhibitorDrugBank|TdgClinicalTrial|ChemblInteractions|TEND11752352|160197638.711.17TOP2ADEXRAZOXANEinhibitorDrugBank|NCI11179439|17652819|10194547|11046078|12911317|17115008|11752352|11984069|113321557.991.07TOP2ATENIPOSIDEinhibitorDrugBank|TdgClinicalTrial|ChemblInteractions|NCI|TEND8702194|16271071|17361331|17514873|11752352|16480143|94265166.530.88TOP2AMOXIFLOXACINinhibitorDrugBank20802486|20596674|117523525.810.78TOP2AENOXACINinhibitorDrugBank18471102|11752352|100898195.810.78TOP2AETOPOSIDEinhibitorDTC|DrugBank|TdgClinicalTrial|ChemblInteractions|NCI|TEND|GuideToPharmacology25466187|20006518|18258442|8823806|22867019|25240702|26291037|25003995|26216018|26292628|23360284|16271071|23920485|21435753|22867097|16759114|11678653|19386396|24931277|23566520|17361331|25922181|25941559|24507920|24775914|9485461|23353750|25815139|16309315|24012683|19691293|25800514|21644529|22620261|25945730|24334150|17514873|8870683|23711769|11752352|20863598|24095018|26264845|25799376|22364746|16377807|9494516|23968711|18816045|24326278|19783445|94265164.940.66TOP2AAMSACRINEinhibitorDTC|DrugBank|NCI1322791|8823806|10691026|8519659|19155103|22537681|17911018|8632768|19725581|11006484|11716434|11752352|25626146|11473732|13113904.360.59TOP2ALOMEFLOXACINinhibitorDrugBank117523522.90.39TOP2AMITOXANTRONEinhibitorDrugBank|TdgClinicalTrial|NCI|TEND|GuideToPharmacology10451375|11004693|18687447|11752352|9631585|9494516|11278845|94265162.760.19TOP2APEFLOXACINinhibitorDrugBank117523522.180.29TOP2ANORFLOXACINinhibitorDrugBank117523522.180.29TOP2APODOFILOXinhibitorDrugBank|TdgClinicalTrial|TEND16061385|1334447|10783066|11752352|1845848|13313311.70.23TOP2ACIPROFLOXACINinhibitorDrugBank3015015|1323952|117523521.580.21TOP2AIDARUBICINinhibitorDrugBank|TdgClinicalTrial|TEND10203104|8036155|12034365|11836027|11752352|105237991.090.15TOP2AEPIRUBICINinhibitorDrugBank|TdgClinicalTrial|TEND|PharmGKB14728934|16234514|176399971.020.14TOP2ADOXORUBICINinhibitorDTC|DrugBank|TdgClinicalTrial|ClearityFoundationClinicalTrial|TEND|GuideToPharmacology21388138|17016621|17578914|17010609|17351394|26211460|11752352|20170164|17089011|222769980.730.1TOP2AOFLOXACINinhibitorDrugBank28476470.730.1TOP2ADAUNORUBICINinhibitorDTC|DrugBank|TdgClinicalTrial|NCI22260166|1963303|6380596|94945160.520.07TOP2ADACTINOMYCINinhibitorDrugBank77566570.510.07TOP2AVINCRISTINEn/aNCI94945160.150.02TOP2APACLITAXELn/aTdgClinicalTrial-0.090.01TOP2AFLUOROURACILn/aPharmGKB-0.080.01RACGAP1MITOXANTRONEn/aDTC-0.210.02AURKAPAZOPANIBn/aDTC-0.190.02AURKAPACLITAXELn/aCIViC125591750.170.02AURKAFLUOROURACILn/aCIViC259248240.170.02AURKATAMOXIFENn/aCIViC241665010.130.03AURKACISPLATINn/aCIViC25924824|250822610.090.02AURKAFOSTAMATINIBinhibitorDrugBank265165870.060.01AURKASORAFENIBn/aDTC-0.050.01 A hBo(hBB*CJKHaJph!hB5B*CJKH\aJphh1 JCJOJPJQJaJhBCJOJPJQJaJAFKmu{ $$1$Ifa$ dhG$TIIIIIII $$1$Ifa$kd$$IfT֞C1481 df4aTTIIIIIII $$1$Ifa$kd$$IfT֞C1481 df4aT    TIIIIIII $$1$Ifa$kdT$$IfT֞C1481 df4aT  # 0 : C L Q V TIIIIIII $$1$Ifa$kd$$IfT֞C1481 df4aTV W ] h r TIIIIIII $$1$Ifa$kd$$IfT֞C1481 df4aT ; 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