Supplementary Table 8. KEGG_org_con.,,,
category,pathway,goseq,plage
3010,Ribosome,7.89E-25,3.34E-07
4114,Oocyte meiosis,0.000810115,2.08E-05
280,"Valine, leucine and isoleucine degradation",0.001187396,0.0003469
5012,Parkinson disease,0.002725666,0.000133817
4510,Focal adhesion,0.003656105,7.46E-06
4530,Tight junction,0.004661771,0.000833938
5010,Alzheimer disease,0.006432569,0.000102062
3050,Proteasome,0.007688198,7.42E-05
640,Propanoate metabolism,0.009507226,0.000198131
4720,Long-term potentiation,0.010848707,3.16E-06
5016,Huntington disease,0.016619815,0.0002271
71,Fatty acid degradation,0.01779788,7.21E-05
190,Oxidative phosphorylation,0.018140404,0.000207945
4670,Leukocyte transendothelial migration,0.018794999,0.023733587
3040,Spliceosome,0.022320744,0.00208283
3060,Protein export,0.027580785,0.000912415
5130,Pathogenic Escherichia coli infection,0.030211064,2.07E-05
4914,Progesterone-mediated oocyte maturation,0.031817,7.92E-05
4722,Neurotrophin signaling pathway,0.035505038,0.000215791
4910,Insulin signaling pathway,0.037901638,0.000271195
4146,Peroxisome,0.038301008,5.21E-05
5214,Glioma,0.042532396,0.000126
5100,Bacterial invasion of epithelial cells,0.044981627,8.09E-06
630,Glyoxylate and dicarboxylate metabolism,0.046664896,2.38E-06
480,Glutathione metabolism,0.049232674,0.000912879
4666,Fc gamma R-mediated phagocytosis,0.051164626,1.52E-05
2010,ABC transporters,0.051828779,6.97E-05
3018,RNA degradation,0.053933906,0.003712406
5412,Arrhythmogenic right ventricular cardiomyopathy (ARVC),0.055015443,0.000270518
4012,ErbB signaling pathway,0.056565738,0.000664805
3013,RNA transport,0.07061656,0.001261285
5145,Toxoplasmosis,0.071661932,0.296400291
4612,Antigen processing and presentation,0.071811416,5.28E-05
5223,Non-small cell lung cancer,0.072866394,0.000250223
5212,Pancreatic cancer,0.073047022,0.001215619
4370,VEGF signaling pathway,0.075030907,3.75E-05
650,Butanoate metabolism,0.080851996,0.000228256
4660,T cell receptor signaling pathway,0.086495466,0.000752894
5110,Vibrio cholerae infection,0.086611918,2.05E-07
240,Pyrimidine metabolism,0.088835484,0.000696
4270,Vascular smooth muscle contraction,0.093919128,8.91E-08
4520,Adherens junction,0.095150098,0.000353826
5216,Thyroid cancer,0.099252414,5.54E-05
4320,Dorso-ventral axis formation,0.101284985,5.65E-06
5140,Leishmaniasis,0.112530944,0.107904627
760,Nicotinate and nicotinamide metabolism,0.112742346,0.001185949
4010,MAPK signaling pathway,0.115264757,0.003030628
20,Citrate cycle (TCA cycle),0.116519545,0.012145012
4145,Phagosome,0.117162736,0.008024293
4930,Type II diabetes mellitus,0.117441021,1.65E-05
5213,Endometrial cancer,0.121566412,0.000234433
4210,Apoptosis,0.121749376,0.008727765
232,Caffeine metabolism,0.139131283,0.000188564
61,Fatty acid biosynthesis,0.141964581,0.019719935
5410,Hypertrophic cardiomyopathy (HCM),0.142432027,0.000209056
4730,Long-term depression,0.144733978,9.10E-07
5416,Viral myocarditis,0.146911967,0.001040868
1040,Biosynthesis of unsaturated fatty acids,0.156672162,0.02334535
5414,Dilated cardiomyopathy (DCM),0.161197545,0.000150252
4512,ECM-receptor interaction,0.169286023,0.000415904
5221,Acute myeloid leukemia,0.170256402,0.001714204
4260,Cardiac muscle contraction,0.180520049,5.90E-07
4380,Osteoclast differentiation,0.182097797,0.545253402
5160,Hepatitis C,0.186748411,0.011185878
5120,Epithelial cell signaling in Helicobacter pylori infection,0.18999678,0.101949014
5146,Amoebiasis,0.190091796,0.002332609
670,One carbon pool by folate,0.191767476,0.01621339
531,Glycosaminoglycan degradation,0.200137168,0.016276526
592,alpha-Linolenic acid metabolism,0.210408411,0.000715913
5220,Chronic myeloid leukemia,0.21458369,0.00224125
5014,Amyotrophic lateral sclerosis (ALS),0.216317278,0.004240822
4912,GnRH signaling pathway,0.226475493,8.16E-05
4020,Calcium signaling pathway,0.231862623,0.001434531
4664,Fc epsilon RI signaling pathway,0.241519313,0.000348985
5222,Small cell lung cancer,0.248297399,0.839000912
5219,Bladder cancer,0.25512793,0.000118478
4144,Endocytosis,0.257670706,0.005982059
4650,Natural killer cell mediated cytotoxicity,0.262087744,0.000828165
5211,Renal cell carcinoma,0.300565617,0.001489203
5142,Chagas disease (American trypanosomiasis),0.301937537,0.015246683
410,beta-Alanine metabolism,0.309806104,0.000144719
5131,Shigellosis,0.313357065,0.000671586
62,Fatty acid elongation,0.317698649,0.003018715
780,Biotin metabolism,0.320854264,0.007086005
620,Pyruvate metabolism,0.324884108,1.80E-05
4810,Regulation of actin cytoskeleton,0.326680339,0.371475795
72,Synthesis and degradation of ketone bodies,0.328630971,5.75E-05
4110,Cell cycle,0.332119205,0.000516877
4662,B cell receptor signaling pathway,0.351440491,0.006844273
4350,TGF-beta signaling pathway,0.361899483,0.021230904
5200,Pathways in cancer,0.376987526,0.124961713
920,Sulfur metabolism,0.383429272,0.063123631
4622,RIG-I-like receptor signaling pathway,0.389849048,0.269259455
4150,mTOR signaling pathway,0.393765682,0.00501942
4621,NOD-like receptor signaling pathway,0.401306359,0.058106843
5340,Primary immunodeficiency,0.401404823,0.004380223
785,Lipoic acid metabolism,0.40213567,0.002204248
590,Arachidonic acid metabolism,0.402208925,0.008704086
4972,Pancreatic secretion,0.410234318,0.00142186
5330,Allograft rejection,0.412441804,0.009637368
4120,Ubiquitin mediated proteolysis,0.43277582,0.000976146
740,Riboflavin metabolism,0.457966154,2.29E-07
900,Terpenoid backbone biosynthesis,0.465561115,4.56E-05
4141,Protein processing in endoplasmic reticulum,0.465656757,0.009310206
5150,Staphylococcus aureus infection,0.469662,0.0108892
4920,Adipocytokine signaling pathway,0.480632746,0.138428506
330,Arginine and proline metabolism,0.481288047,3.70E-06
340,Histidine metabolism,0.483342384,0.054970218
4514,Cell adhesion molecules (CAMs),0.490765739,0.008898716
5322,Systemic lupus erythematosus,0.492293927,0.091464628
3008,Ribosome biogenesis in eukaryotes,0.501595215,0.001682698
790,Folate biosynthesis,0.505254543,0.000304471
4062,Chemokine signaling pathway,0.50727964,0.321380042
4310,Wnt signaling pathway,0.522308934,0.032818161
4940,Type I diabetes mellitus,0.531198901,0.047901516
4962,Vasopressin-regulated water reabsorption,0.538946071,0.000316695
3015,mRNA surveillance pathway,0.546825011,0.008468272
3420,Nucleotide excision repair,0.552044691,0.011568636
360,Phenylalanine metabolism,0.560660773,0.012192186
4744,Phototransduction,0.560819835,7.01E-05
4330,Notch signaling pathway,0.574284354,0.000107776
5218,Melanoma,0.574992998,0.517629878
4977,Vitamin digestion and absorption,0.579920444,0.165284357
565,Ether lipid metabolism,0.58362345,0.172935153
5210,Colorectal cancer,0.608587534,0.007143076
5332,Graft-versus-host disease,0.63079627,0.014246177
524,"Neomycin, kanamycin and gentamicin biosynthesis",0.633008454,0.000174282
1100,Metabolic pathways,0.637769694,0.003617942
4070,Phosphatidylinositol signaling system,0.643516599,0.027014802
910,Nitrogen metabolism,0.648478851,0.859631995
4130,SNARE interactions in vesicular transport,0.652982192,0.000305039
3020,RNA polymerase,0.655029571,0.018728804
4140,Autophagy - animal,0.663849876,0.000913166
860,Porphyrin and chlorophyll metabolism,0.665804898,0.646199429
750,Vitamin B6 metabolism,0.682985898,0.001304037
5310,Asthma,0.68486542,0.188403933
5215,Prostate cancer,0.685620878,0.001940842
520,Amino sugar and nucleotide sugar metabolism,0.687396155,0.000102052
564,Glycerophospholipid metabolism,0.68810966,0.274189942
120,Primary bile acid biosynthesis,0.702126418,0.060933042
512,Mucin type O-glycan biosynthesis,0.702462496,0.058602146
130,Ubiquinone and other terpenoid-quinone biosynthesis,0.706058672,0.146262954
3320,PPAR signaling pathway,0.708048518,0.948881629
770,Pantothenate and CoA biosynthesis,0.712239609,0.001415092
5320,Autoimmune thyroid disease,0.714856196,0.027611066
4360,Axon guidance,0.71944394,0.000501379
563,Glycosylphosphatidylinositol (GPI)-anchor biosynthesis,0.720378523,0.193691808
4142,Lysosome,0.72269616,0.636923862
4640,Hematopoietic cell lineage,0.728290942,0.004095694
10,Glycolysis / Gluconeogenesis,0.731335907,0.003007353
511,Other glycan degradation,0.747320223,0.299272912
450,Selenocompound metabolism,0.755713831,0.017654698
4710,Circadian rhythm,0.761324124,0.057878798
533,Glycosaminoglycan biosynthesis - keratan sulfate,0.762704226,0.109596075
561,Glycerolipid metabolism,0.769598431,0.243744247
230,Purine metabolism,0.771346592,0.052796311
5020,Prion diseases,0.7752851,0.029734752
140,Steroid hormone biosynthesis,0.785416676,0.156434536
4122,Sulfur relay system,0.797354882,0.192701345
3410,Base excision repair,0.800365047,8.77E-05
510,N-Glycan biosynthesis,0.801540011,0.224009756
4540,Gap junction,0.803944144,0.000884572
53,Ascorbate and aldarate metabolism,0.804077566,0.084533044
4971,Gastric acid secretion,0.808583209,6.94E-05
430,Taurine and hypotaurine metabolism,0.809040371,0.031787841
970,Aminoacyl-tRNA biosynthesis,0.815160183,0.002874268
3022,Basal transcription factors,0.827254135,0.085280428
4966,Collecting duct acid secretion,0.839887086,0.021035583
380,Tryptophan metabolism,0.840810515,0.004799442
4973,Carbohydrate digestion and absorption,0.841157781,0.003844527
534,Glycosaminoglycan biosynthesis - heparan sulfate / heparin,0.841468496,0.089175566
4620,Toll-like receptor signaling pathway,0.851094318,0.858500885
4115,p53 signaling pathway,0.85520961,0.058666664
4970,Salivary secretion,0.855986097,0.000438239
4976,Bile secretion,0.8562238,0.002175482
290,"Valine, leucine and isoleucine biosynthesis",0.858386542,0.008547002
4960,Aldosterone-regulated sodium reabsorption,0.859419364,0.236790833
3030,DNA replication,0.862024301,0.004642459
310,Lysine degradation,0.862857628,0.004071883
5143,African trypanosomiasis,0.864730486,0.013115059
591,Linoleic acid metabolism,0.870183581,0.010912391
270,Cysteine and methionine metabolism,0.870643344,0.00015091
4916,Melanogenesis,0.885139918,0.000441777
514,Other types of O-glycan biosynthesis,0.89558671,0.084826339
350,Tyrosine metabolism,0.89635102,0.067318957
4964,Proximal tubule bicarbonate reclamation,0.89923235,0.04715545
562,Inositol phosphate metabolism,0.899919734,0.053389706
4950,Maturity onset diabetes of the young,0.903656374,0.11899719
4630,JAK-STAT signaling pathway,0.905642418,0.02972568
830,Retinol metabolism,0.906246665,0.033574416
532,Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate,0.907518304,0.06548139
40,Pentose and glucuronate interconversions,0.912877067,0.228260445
260,"Glycine, serine and threonine metabolism",0.921779921,5.99E-06
3450,Non-homologous end-joining,0.924825267,0.010772102
603,Glycosphingolipid biosynthesis - globo and isoglobo series,0.927197585,0.546596528
250,"Alanine, aspartate and glutamate metabolism",0.928433139,0.019344431
4974,Protein digestion and absorption,0.937610391,0.00386141
4623,Cytosolic DNA-sensing pathway,0.940381504,0.696667147
980,Metabolism of xenobiotics by cytochrome P450,0.941684801,0.092129631
600,Sphingolipid metabolism,0.94502246,0.178953736
52,Galactose metabolism,0.947865606,0.068573994
4614,Renin-angiotensin system,0.949667672,0.006059577
982,Drug metabolism - cytochrome P450,0.949733568,0.07308077
983,Drug metabolism - other enzymes,0.955502216,0.943636322
3440,Homologous recombination,0.958169977,0.617592425
51,Fructose and mannose metabolism,0.958457333,6.79E-05
5323,Rheumatoid arthritis,0.958979898,0.030892755
4672,Intestinal immune network for IgA production,0.968330447,0.018395619
4340,Hedgehog signaling pathway,0.974945089,0.001451117
500,Starch and sucrose metabolism,0.981660805,0.151796375
601,Glycosphingolipid biosynthesis - lacto and neolacto series,0.983242396,0.041357191
3430,Mismatch repair,0.986384691,0.002778883
4742,Taste transduction,0.988899519,0.008236958
30,Pentose phosphate pathway,0.989151852,0.496038069
4975,Fat digestion and absorption,0.991064432,0.153950088
5144,Malaria,0.992669816,0.034158718
4610,Complement and coagulation cascades,0.992820706,0.013943933
4060,Cytokine-cytokine receptor interaction,0.994895636,0.015086573
5217,Basal cell carcinoma,0.998915548,0.01763057
4080,Neuroactive ligand-receptor interaction,0.999996143,0.018910674
4740,Olfactory transduction,0.999999833,0.167222767
300,Lysine biosynthesis,1,0.076601363
472,D-Arginine and D-ornithine metabolism,1,1
400,"Phenylalanine, tyrosine and tryptophan biosynthesis",1,3.24E-06
100,Steroid biosynthesis,1,0.081189382
460,Cyanoamino acid metabolism,1,0.436444577
604,Glycosphingolipid biosynthesis - ganglio series,1,0.249246242
471,D-Glutamine and D-glutamate metabolism,1,0.074531587
730,Thiamine metabolism,1,0.607994867