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Warning Text %XTableStyleMedium2PivotStyleLight16`Table S14  numqvalueclassID DescrptionUpDownTNF signaling pathway$Environmental Information Processingko04668HTLV-I infectionHuman Diseasesko05166Human cytomegalovirus infectionko05163 ApoptosisCellular Processesko04210NF-kappa B signaling pathwayko04064Prion diseasesko05020&Cytokine-cytokine receptor interactionko04060IL-17 signaling pathwayOrganismal Systemsko04657/Kaposi sarcoma-associated herpesvirus infectionko05167=Viral protein interaction with cytokine and cytokine receptorko04061Insulin resistanceko04931HIF-1 signaling pathwayko04066 Shigellosisko05131FoxO signaling pathwayko04068(Transcriptional misregulation in cancersko05202)Non-alcoholic fatty liver disease (NAFLD)ko04932p53 signaling pathwayko04115 Necroptosisko04217 Hepatitis Bko05161Rheumatoid arthritisko05323Platinum drug resistanceko01524 Influenza Ako05164Human papillomavirus infectionko05165%Longevity regulating pathway - mammalko042114AGE-RAGE signaling pathway in diabetic complicationsko04933Salmonella infectionko051323Parathyroid hormone synthesis, secretion and actionko04928)Chagas disease (American trypanosomiasis)ko05142Antifolate resistanceko01523Th17 cell differentiationko04659Apoptosis - multiple speciesko04215Graft-versus-host diseaseko05332 Tuberculosisko05152Thyroid cancerko05216Bladder cancerko05219%Pathogenic Escherichia coli infectionko05130Measlesko05162 Hepatitis Cko05160Cellular senescenceko04218Malariako05144#Amyotrophic lateral sclerosis (ALS)ko05014 Legionellosisko05134Endometrial cancerko05213Cytosolic DNA-sensing pathwayko04623Basal cell carcinomako05217Pathways in cancerko05200/Neomycin, kanamycin and gentamicin biosynthesis Metabolismko00524Non-small cell lung cancerko05223!Inflammatiory bowel disease (IBD)ko05321#Central carbon metabolism in cancerko05230Renal cell carcinomako05211Melanomako05218Viral carcinogenesisko05203 Pertussisko05133Gliomako05214Chronic myeloid leukemiako05220Pancreatic cancerko05212class 7Table S2 KEGG analysis  7 GO:0044421extracellular region partCellular Component GO:0005576extracellular region GO:0005615extracellular space GO:0005739 mitochondrion GO:0031012extracellular matrix GO:0031967organelle envelope GO:0031975envelope GO:0031974membrane-enclosed lumen GO:0043233organelle lumen GO:0070013intracellular organelle lumen GO:0097144 BAX complex GO:0099020'perinuclear endoplasmic reticulum lumen GO:0070557PCNA-p21 complex GO:0097145 BAK complex GO:0005635nuclear envelope GO:0005637nuclear inner membrane GO:0031968organelle outer membrane GO:0019867outer membrane GO:0005896interleukin-6 receptor complex GO:0043231(intracellular membrane-bounded organelle GO:0005102signaling receptor bindingMolecular Function GO:0005125cytokine activity GO:0048018receptor ligand activity GO:0030545receptor regulator activity GO:0051400BH domain binding GO:0044877"protein-containing complex binding GO:0046983protein dimerization activity GO:0005126cytokine receptor binding GO:0050839cell adhesion molecule binding GO:0005178integrin binding GO:0046982#protein heterodimerization activity GO:0008083growth factor activity GO:0019912:cyclin-dependent protein kinase activating kinase activity GO:0048156tau protein binding GO:0048020CCR chemokine receptor binding GO:0008009chemokine activity GO:0031732CCR7 chemokine receptor binding GO:0004677%DNA-dependent protein kinase activity GO:0031735 CCR10 chemokine receptor binding GO:0042379chemokine receptor binding GO:0004340glucokinase activity GO:0004396hexokinase activity GO:0004784superoxide dismutase activity GO:0008865fructokinase activity GO:0016721Boxidoreductase activity, acting on superoxide radicals as acceptor GO:0019158mannokinase activity GO:0043120tumor necrosis factor binding GO:0031625 ubiquitin protein ligase binding GO:0044389%ubiquitin-like protein ligase binding GO:0051434BH3 domain binding GO:0098772molecular function regulator GO:0004222metalloendopeptidase activity GO:0051087chaperone binding GO:0010033response to organic substanceBiological Process GO:0097193%intrinsic apoptotic signaling pathway GO:0071310&cellular response to organic substance GO:0070887&cellular response to chemical stimulus GO:0033554cellular response to stress GO:0042981regulation of apoptotic process GO:0043067#regulation of programmed cell death GO:0019221#cytokine-mediated signaling pathway GO:0097190apoptotic signaling pathway GO:0042327&positive regulation of phosphorylation GO:0010941regulation of cell death GO:0008630?intrinsic apoptotic signaling pathway in response to DNA damage GO:00105623positive regulation of phosphorus metabolic process GO:00459372positive regulation of phosphate metabolic process GO:0007166'cell surface receptor signaling pathway GO:0042221response to chemical GO:0009628response to abiotic stimulus GO:0080135)regulation of cellular response to stress GO:0060548!negative regulation of cell death GO:1902531/regulation of intracellular signal transduction GO:0006915apoptotic process GO:0001934.positive regulation of protein phosphorylation GO:0042325regulation of phosphorylation GO:00322709positive regulation of cellular protein metabolic process GO:0044087+regulation of cellular component biogenesis GO:1903626,positive regulation of DNA catabolic process GO:00512470positive regulation of protein metabolic process GO:00313251positive regulation of cellular metabolic process GO:0035556!intracellular signal transduction GO:0012501programmed cell death GO:0071345&cellular response to cytokine stimulus GO:19025338positive regulation of intracellular signal transduction GO:0080134 regulation of response to stress GO:0043066(negative regulation of apoptotic process GO:0001932%regulation of protein phosphorylation GO:0043068,positive regulation of programmed cell death GO:0043069,negative regulation of programmed cell death GO:0019220)regulation of phosphate metabolic process GO:0051174*regulation of phosphorus metabolic process GO:0008219 cell death GO:0048585+negative regulation of response to stimulus GO:0051128-regulation of cellular component organization GO:0034097response to cytokine GO:0070661leukocyte proliferation GO:0031399*regulation of protein modification process GO:0007165signal transduction GO:0010942!positive regulation of cell death GO:0009966!regulation of signal transduction GO:0009893(positive regulation of metabolic process GO:00314013positive regulation of protein modification process GO:0006950response to stress GO:0071214%cellular response to abiotic stimulus GO:0104004+cellular response to environmental stimulus GO:0051173:positive regulation of nitrogen compound metabolic process GO:0008283cell proliferation GO:0032963collagen metabolic process GO:0048523'negative regulation of cellular process GO:0030335%positive regulation of cell migration GO:0009968*negative regulation of signal transduction GO:0048583"regulation of response to stimulus GO:2000147$positive regulation of cell motility GO:0042127 regulation of cell proliferation GO:0009967*positive regulation of signal transduction GO:00106046positive regulation of macromolecule metabolic process GO:0016310phosphorylation GO:00512722positive regulation of cellular component movement GO:20012342negative regulation of apoptotic signaling pathway GO:0048584+positive regulation of response to stimulus GO:004001< 7!positive regulation of locomotion GO:1903624#regulation of DNA catabolic process GO:0072359circulatory system development GO:0070482response to oxygen levels GO:0023052 signaling GO:0051094,positive regulation of developmental process GO:0010648)negative regulation of cell communication GO:0023057 negative regulation of signaling GO:0007154cell communication GO:00313311positive regulation of cellular catabolic process GO:0010332response to gamma radiation GO:0051716cellular response to stimulus GO:0010646 regulation of cell communication GO:0023051regulation of signaling GO:0010647)positive regulation of cell communication GO:00322680regulation of cellular protein metabolic process GO:0023056 positive regulation of signaling GO:0043065(positive regulation of apoptotic process GO:0072593)reactive oxygen species metabolic process GO:0016477cell migration GO:0150076neuroinflammatory response GO:0009314response to radiation GO:0046651lymphocyte proliferation GO:0048522'positive regulation of cellular process GO:0032943mononuclear cell proliferation GO:20012423regulation of intrinsic apoptotic signaling pathway GO:0098586cellular response to virus GO:0033993response to lipid GO:0009896(positive regulation of catabolic process GO:0048518)positive regulation of biological process GO:0048519)negative regulation of biological process GO:0006468protein phosphorylation GO:0007568aging GO:0051246'regulation of protein metabolic process GO:0071347"cellular response to interleukin-1 GO:1901700&response to oxygen-containing compound GO:0050896response to stimulus GO:00511306positive regulation of cellular component organization GO:0009725response to hormone GO:0051707response to other organism GO:0043207$response to external biotic stimulus GO:0043410#positive regulation of MAPK cascade GO:20003777regulation of reactive oxygen species metabolic process GO:0048870 cell motility GO:0051674localization of cell GO:0071478cellular response to radiation GO:0010575Dpositive regulation of vascular endothelial growth factor production GO:0002521leukocyte differentiation GO:0044093)positive regulation of molecular function GO:0043085)positive regulation of catalytic activity GO:0009607response to biotic stimulus GO:0070555response to interleukin-1 GO:0036293#response to decreased oxygen levels GO:0002682#regulation of immune system process GO:2001243<negative regulation of intrinsic apoptotic signaling pathway GO:0030947Kregulation of vascular endothelial growth factor receptor signaling pathway GO:0071480$cellular response to gamma radiation GO:0010574;regulation of vascular endothelial growth factor production GO:0030098lymphocyte differentiation GO:0060574%intestinal epithelial cell maturation GO:0001775cell activation GO:0009605response to external stimulus GO:2000379@positive regulation of reactive oxygen species metabolic process GO:0050670&regulation of lymphocyte proliferation GO:0150077(regulation of neuroinflammatory response GO:2001233)regulation of apoptotic signaling pathway GO:0032944,regulation of mononuclear cell proliferation GO:0071887leukocyte apoptotic process GO:0010573-vascular endothelial growth factor production GO:0030334regulation of cell migration GO:0032879regulation of localization GO:0050867&positive regulation of cell activation GO:0050865regulation of cell activation GO:0002376immune system process GO:0070663%regulation of leukocyte proliferation GO:19025122positive regulation of apoptotic DNA fragmentation GO:0002684,positive regulation of immune system process GO:0040011 locomotion GO:0051704multi-organism process GO:0030097 hemopoiesis GO:0021987cerebral cortex development GO:0006954inflammatory response GO:0006308DNA catabolic process GO:2000145regulation of cell motility GO:0048869cellular developmental process GO:0006796/phosphate-containing compound metabolic process GO:1902339Bpositive regulation of apoptotic process involved in morphogenesis GO:1904747@positive regulation of apoptotic process involved in development GO:0048534+hematopoietic or lymphoid organ development GO:0006793phosphorus metabolic process GO:0001774microglial cell activation GO:0008285)negative regulation of cell proliferation GO:0046330"positive regulation of JNK cascade GO:0009888tissue development GO:0001944vasculature development GO:0072358!cardiovascular system development GO:0045321leukocyte activation GO:0050671/positive regulation of lymphocyte proliferation GO:00329465positive regulation of mononuclear cell proliferation GO:0045597+positive regulation of cell differentiation GO:0043408regulation of MAPK cascade GO:00022696leukocyte activation involved in inflammatory response GO:0002069,columnar/cuboidal epithelial cell maturation GO:0070372#regulation of ERK1 and ERK2 cascade GO:0002687*positive regulation of leukocyte migration GO:0040012regulation of locomotion GO:0002520immune system development GO:0030183B cell differentiation GO:0090068)positive regulation of cell cycle process GO:0050729,positive regulation of inflammatory response GO:0032101+regulation of response to external stimulus GO:0051270)regulation of cellular component movement GO:0010212response to ionizing radiation GO:0014009glial cell proliferation GO:0007417"central nervous system development GO:0070665.positive regulation of leukocyte proliferation GO:0061900glial cell activation GO:0042063 gliogenesis GO:0000077DNA damage checkpoint GO:0032364oxygen homeostasis GO:0033129.positive regulation of histone phosphorylation GO:1903896>positive regulation of IRE1-mediated unfolded protein response GO:0022607cellular component assembly GO:1903428Cpositive regulation of reactive oxygen species biosynthetic process GO:0051249#regulation of lymphocyte activation GO:0000187activation of MAPK activity GO:0046649lymphocyte activation GO:0070371ERK1 and ERK2 cascade GO:00511711regulation of nitrogen compound metabolic process GO:0006928)movement of cell or subcellular component GO:0001541ovarian follicle development GO:1901214regulation of neuron death GO:0048513animal organ development GO:0031570DNA integrity checkpoint GO:0045860.positive regulation of protein kinase activity GO:0050793#regulation of developmental process GO:19025328negative regulation of intracellular signal transduction GO:0006977]DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:00512407positive regulation of multicellular organismal process GO:0043254&regulation of protein complex assembly GO:0072431@signal transduction involved in mitotic G1 DNA damage checkpoint GO:1902400Fintracellular signal transduction involved in G1 DNA damage checkpoint GO:00328744positive regulation of stress-activated MAPK cascade GO:0001836)release of cytochrome c from mitochondria GO:1902402=signal transduction involved in mitotic DNA damage checkpoint GO:1902403@signal transduction involved in mitotic DNA integrity checkpoint GO:00321034positive regulation of response to external stimulus GO:0070304Hpositive regulation of stress-activated protein kinase signaling cascade GO:00019591regulation of cytokine-mediated signaling pathway GO:0031960response to corticosteroid GO:0042113B cell activation GO:0072413=signal transduction involved in mitotic cell cycle checkpoint GO:0030154cell differentiation GO:0006351transcription, DNA-templated GO:0097659$nucleic acid-templated transcription GO:0048771tissue remodeling GO:0009889"regulation of biosynthetic process GO:0080090'regulation of primary metabolic process GO:00346543nucleobase-con< taining compound biosynthetic process GO:0032774RNA biosynthetic process GO:00440894positive regulation of cellular component biogenesis GO:0048731system development GO:0021543pallium development GO:0060759+regulation of response to cytokine stimulus GO:1901701/cellular response to oxygen-containing compound GO:0045595"regulation of cell differentiation GO:0031571 mitotic G1 DNA damage checkpoint GO:0009615response to virus GO:0001666response to hypoxia GO:0033483gas homeostasis GO:00468863positive regulation of hormone biosynthetic process GO:1902510)regulation of apoptotic DNA fragmentation GO:0046328regulation of JNK cascade GO:0070997 neuron death GO:0002548monocyte chemotaxis GO:0044783G1 DNA damage checkpoint GO:0044819"mitotic G1/S transition checkpoint GO:0018130 heterocycle biosynthetic process GO:0019438&aromatic compound biosynthetic process GO:0031323(regulation of cellular metabolic process GO:0050727#regulation of inflammatory response GO:0032722+positive regulation of chemokine production GO:0051251,positive regulation of lymphocyte activation GO:0060255-regulation of macromolecule metabolic process GO:0006952defense response GO:19023379regulation of apoptotic process involved in morphogenesis GO:19047487regulation of apoptotic process involved in development GO:0071479'cellular response to ionizing radiation GO:0002694"regulation of leukocyte activation GO:0033674&positive regulation of kinase activity GO:0048514blood vessel morphogenesis GO:0038034(signal transduction in absence of ligand GO:0097192:extrinsic apoptotic signaling pathway in absence of ligand GO:0044085cellular component biogenesis GO:00724018signal transduction involved in DNA integrity checkpoint GO:00724225signal transduction involved in DNA damage checkpoint GO:0050864regulation of B cell activation GO:0045862"positive regulation of proteolysis GO:0006974(cellular response to DNA damage stimulus GO:0030949Tpositive regulation of vascular endothelial growth factor receptor signaling pathway GO:0033127%regulation of histone phosphorylation GO:0060576&intestinal epithelial cell development GO:00723955signal transduction involved in cell cycle checkpoint GO:0042098T cell proliferation GO:0009891+positive regulation of biosynthetic process GO:1903708"positive regulation of hemopoiesis GO:0045787!positive regulation of cell cycle GO:0014823response to activity GO:0060260Fregulation of transcription initiation from RNA polymerase II promoter GO:0035966+response to topologically incorrect protein GO:1901362,organic cyclic compound biosynthetic process GO:0070278*extracellular matrix constituent secretion GO:01500781positive regulation of neuroinflammatory response GO:1900103Fpositive regulation of endoplasmic reticulum unfolded protein response GO:0002685!regulation of leukocyte migration GO:0000075cell cycle checkpoint GO:0043523&regulation of neuron apoptotic process GO:0008284)positive regulation of cell proliferation GO:0022617 extracellular matrix disassembly GO:0048145&regulation of fibroblast proliferation GO:20001129regulation of cellular macromolecule biosynthetic process GO:0031329(regulation of cellular catabolic process GO:0048144fibroblast proliferation GO:2000106)regulation of leukocyte apoptotic process GO:0007254 JNK cascade GO:0002070epithelial cell maturation GO:19038945regulation of IRE1-mediated unfolded protein response GO:0002696+positive regulation of leukocyte activation GO:0000165 MAPK cascade GO:0023014.signal transduction by protein phosphorylation GO:0014070#response to organic cyclic compound GO:0097529myeloid leukocyte migration GO:00105560regulation of macromolecule biosynthetic process GO:0050794regulation of cellular process GO:0071158(positive regulation of cell cycle arrest GO:20001425regulation of DNA-templated transcription, initiation GO:0030198!extracellular matrix organization GO:00323520positive regulation of hormone metabolic process GO:0090399replicative senescence GO:0002064epithelial cell development GO:0070098$chemokine-mediated signaling pathway GO:0097191%extrinsic apoptotic signaling pathway GO:0009719response to endogenous stimulus GO:00063678transcription initiation from RNA polymerase II promoter GO:20000262regulation of multicellular organismal development GO:0006355*regulation of transcription, DNA-templated GO:19035062regulation of nucleic acid-templated transcription GO:0000302#response to reactive oxygen species GO:19001193positive regulation of execution phase of apoptosis GO:1901550*regulation of endothelial cell development GO:19031402regulation of establishment of endothelial barrier GO:0001776leukocyte homeostasis GO:0034644cellular response to UV GO:0065007biological regulation GO:0051347+positive regulation of transferase activity GO:0032872+regulation of stress-activated MAPK cascade GO:2001141&regulation of RNA biosynthetic process GO:0001568blood vessel development GO:00511492positive regulation of muscle cell differentiation GO:0048856 anatomical structure development GO:0010468regulation of gene expression GO:0070302?regulation of stress-activated protein kinase signaling cascade GO:0016043cellular component organization GO:0032642"regulation of chemokine production GO:0071363+cellular response to growth factor stimulus GO:00357433CD4-positive, alpha-beta T cell cytokine production GO:0060252/positive regulation of glial cell proliferation GO:0070242thymocyte apoptotic process GO:1903978(regulation of microglial cell activation GO:0032602chemokine production GO:0048010=vascular endothelial growth factor receptor signaling pathway GO:0071674mononuclear cell migration GO:0031347regulation of defense response GO:1901216#positive regulation of neuron death GO:1903426:regulation of reactive oxygen species biosynthetic process GO:19058976regulation of response to endoplasmic reticulum stress GO:0051402neuron apoptotic process GO:0008585female gonad development GO:1990868response to chemokine GO:1990869cellular response to chemokine GO:00327607positive regulation of tumor necrosis factor production GO:0048468cell development GO:0051054,positive regulation of DNA metabolic process GO:0060249 anatomical structure homeostasis GO:0006979response to oxidative stress GO:0042116macrophage activation GO:00431221regulation of I-kappaB kinase/NF-kappaB signaling GO:0042100B cell proliferation GO:0070848response to growth factor GO:00468272positive regulation of protein export from nucleus GO:1902176Unegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:0051049regulation of transport GO:0042102+positive regulation of T cell proliferation GO:0031326+regulation of cellular biosynthetic process GO:00465454development of primary female sexual characteristics GO:1903557Lpositive regulation of tumor necrosis factor superfamily cytokine production GO:0035295tube development GO:0051052#regulation of DNA metabolic process GO:0002824positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:1900017Lpositive regulation of cytokine production involved in inflammatory response GO:0007275"multicellular organism development GO:0043406*positive regulation of MAP kinase activity GO:0009653"anatomical structure morphogenesis GO:0044773mitotic DNA damage checkpoint GO:0009894regulation of catabolic process GO:0043062$extracellular structure organization GO:0021537telencephalon development GO:0007569 cell aging GO:2000134<negative regulation of G1/S transition of mitotic cell cycle GO:0002827< 6positive regulation of T-helper 1 type immune response GO:0060575*intestinal epithelial cell differentiation GO:0019222regulation of metabolic process GO:0002821/positive regulation of adaptive immune response GO:00456211positive regulation of lymphocyte differentiation GO:0071840-cellular component organization or biogenesis GO:0065003#protein-containing complex assembly GO:0044774 mitotic DNA integrity checkpoint GO:0051239.regulation of multicellular organismal process GO:0030330>DNA damage response, signal transduction by p53 class mediator GO:19028077negative regulation of cell cycle G1/S phase transition GO:0007095 mitotic G2 DNA damage checkpoint GO:0035988chondrocyte proliferation GO:0071156regulation of cell cycle arrest GO:00226030regulation of anatomical structure morphogenesis GO:0034645+cellular macromolecule biosynthetic process GO:00486468anatomical structure formation involved in morphogenesis GO:00027261positive regulation of T cell cytokine production GO:1901889-negative regulation of cell junction assembly GO:1904706@negative regulation of vascular smooth muscle cell proliferation GO:0046660female sex differentiation GO:0051252#regulation of RNA metabolic process GO:0001819*positive regulation of cytokine production GO:0050900leukocyte migration GO:0006366"transcription by RNA polymerase II GO:0006309apoptotic DNA fragmentation GO:0060561+apoptotic process involved in morphogenesis GO:0051403stress-activated MAPK cascade GO:0045859%regulation of protein kinase activity GO:00719006regulation of protein serine/threonine kinase activity GO:1901698response to nitrogen compound GO:0007249#I-kappaB kinase/NF-kappaB signaling GO:0030100regulation of endocytosis GO:0001525 angiogenesis GO:0044271/cellular nitrogen compound biosynthetic process GO:1903409,reactive oxygen species biosynthetic process GO:0009059"macromolecule biosynthetic process GO:0060396)growth hormone receptor signaling pathway GO:0006352'DNA-templated transcription, initiation GO:0008637apoptotic mitochondrial changes GO:0042592homeostatic process GO:0032502developmental process GO:0046885*regulation of hormone biosynthetic process GO:0031334/positive regulation of protein complex assembly GO:0060322head development GO:00310981stress-activated protein kinase signaling cascade GO:0070727#cellular macromolecule localization GO:0034976(response to endoplasmic reticulum stress GO:0071378,cellular response to growth hormone stimulus GO:1902175Lregulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:00106056negative regulation of macromolecule metabolic process GO:0030968/endoplasmic reticulum unfolded protein response GO:0051223regulation of protein transport GO:00026752positive regulation of acute inflammatory response GO:0002825-regulation of T-helper 1 type immune response GO:0010954)positive regulation of protein processing GO:00313284positive regulation of cellular biosynthetic process GO:0035239tube morphogenesis GO:0001782B cell homeostasis GO:0032770-positive regulation of monooxygenase activity GO:0048147/negative regulation of fibroblast proliferation GO:0050789 regulation of biological process GO:0071901?negative regulation of protein serine/threonine kinase activity GO:0050790 regulation of catalytic activity GO:0042770-signal transduction in response to DNA damage GO:0071482#cellular response to light stimulus GO:0007399nervous system development GO:1900101=regulation of endoplasmic reticulum unfolded protein response GO:1903319)positive regulation of protein maturation GO:0000737&DNA catabolic process, endonucleolytic GO:0090087regulation of peptide transport GO:0022411cellular component disassembly GO:0048660.regulation of smooth muscle cell proliferation GO:0010165response to X-ray GO:0060251&regulation of glial cell proliferation GO:0009416response to light stimulus GO:0071236cellular response to antibiotic GO:0051235maintenance of location GO:0032147%activation of protein kinase activity GO:0048659 smooth muscle cell proliferation GO:0030262apoptotic nuclear changes GO:0031572G2 DNA damage checkpoint GO:00466279negative regulation of insulin receptor signaling pathway GO:0051641cellular localization GO:00702013regulation of establishment of protein localization GO:0043524/negative regulation of neuron apoptotic process GO:0043405!regulation of MAP kinase activity GO:0034620%cellular response to unfolded protein GO:0010831.positive regulation of myotube differentiation GO:0032880"regulation of protein localization GO:0043549regulation of kinase activity GO:0071902?positive regulation of protein serine/threonine kinase activity GO:0051384response to glucocorticoid GO:1901342%regulation of vasculature development GO:0001837$epithelial to mesenchymal transition GO:0009411response to UV GO:0045834.positive regulation of lipid metabolic process GO:0050871(positive regulation of B cell activation GO:0044267"cellular protein metabolic process GO:0006921Gcellular component disassembly involved in execution phase of apoptosis GO:0044818"mitotic G2/M transition checkpoint GO:0045601.regulation of endothelial cell differentiation GO:00511941positive regulation of cofactor metabolic process GO:0051385response to mineralocorticoid GO:1900077<negative regulation of cellular response to insulin stimulus GO:20000453regulation of G1/S transition of mitotic cell cycle GO:0016070RNA metabolic process GO:0002369T cell cytokine production GO:0002724(regulation of T cell cytokine production GO:0045807"positive regulation of endocytosis GO:0002673)regulation of acute inflammatory response GO:0019219>regulation of nucleobase-containing compound metabolic process GO:0002822regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0051179 localization GO:0016572histone phosphorylation GO:0032965+regulation of collagen biosynthetic process GO:1902742)apoptotic process involved in development GO:0002262myeloid cell homeostasis GO:0033036macromolecule localization GO:0001101response to acid chemical GO:0010628&positive regulation of gene expression GO:0032640 tumor necrosis factor production GO:0032680.regulation of tumor necrosis factor production GO:0046825)regulation of protein export from nucleus GO:1905898?positive regulation of response to endoplasmic reticulum stress GO:0007093mitotic cell cycle checkpoint GO:0065009 regulation of molecular function GO:19021070positive regulation of leukocyte differentiation GO:0051147)regulation of muscle cell differentiation GO:0051050 positive regulation of transport GO:00454298positive regulation of nitric oxide biosynthetic process GO:1900117*regulation of execution phase of apoptosis GO:00717065tumor necrosis factor superfamily cytokine production GO:1903555Cregulation of tumor necrosis factor superfamily cytokine production GO:0002460yadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:00013151age-dependent response to reactive oxygen species GO:0003069^acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0032976+release of matrix enzymes from mitochondria GO:1902847*regulation of neuronal signal transduction GO:19029986positive regulation of neurofibrillary tangle assembly GO:19058432regulation of cellular response to gamma radiation GO:1905891/regulation of cellular response to thapsigargin GO:19058928negative regulation of cellular response to thapsigargin GO:1905894.regulation of cellular response to tunicamycin GO:1905895< 7negative regulation of cellular response to tunicamycin GO:1905917Lpositive regulation of cell differentiation involved in phenotypic switching GO:1905932cpositive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching GO:1990117+B cell receptor apoptotic signaling pathway GO:20005497positive regulation of dendritic cell dendrite assembly GO:0060429epithelium development GO:0009892(negative regulation of metabolic process GO:0061061muscle structure development GO:0060341#regulation of cellular localization GO:0007259JAK-STAT cascade GO:00342507positive regulation of cellular amide metabolic process GO:0007257!activation of JUN kinase activity GO:0032350'regulation of hormone metabolic process GO:0060416response to growth hormone GO:19044075positive regulation of nitric oxide metabolic process GO:0044249cellular biosynthetic process GO:00063570regulation of transcription by RNA polymerase II GO:0032007$negative regulation of TOR signaling GO:0032940secretion by cell GO:00359674cellular response to topologically incorrect protein GO:0097696 STAT cascade GO:0010712(regulation of collagen metabolic process GO:0002819&regulation of adaptive immune response GO:0070613 regulation of protein processing GO:00313241negative regulation of cellular metabolic process GO:0042129"regulation of T cell proliferation GO:0048469cell maturation GO:0006464%cellular protein modification process GO:0036211protein modification process GO:0008631Eintrinsic apoptotic signaling pathway in response to oxidative stress GO:1902806.regulation of cell cycle G1/S phase transition GO:1903317 regulation of protein maturation GO:0051093,negative regulation of developmental process GO:1901576&organic substance biosynthetic process GO:0042088T-helper 1 type immune response GO:1900408<negative regulation of cellular response to oxidative stress GO:1903053/regulation of extracellular matrix organization GO:1903202:negative regulation of oxidative stress-induced cell death GO:20001072negative regulation of leukocyte apoptotic process GO:0048545response to steroid hormone GO:0060401cytosolic calcium ion transport GO:0043933/protein-containing complex subunit organization GO:0030900forebrain development GO:0008104protein localization GO:0010638-positive regulation of organelle organization GO:0030574collagen catabolic process GO:0032964collagen biosynthetic process GO:0035722)interleukin-12-mediated signaling pathway GO:0050999,regulation of nitric-oxide synthase activity GO:0044260(cellular macromolecule metabolic process GO:0051649%establishment of localization in cell GO:0006986response to unfolded protein GO:0045619(regulation of lymphocyte differentiation GO:00025345cytokine production involved in inflammatory response GO:00901997regulation of release of cytochrome c from mitochondria GO:1900015Cregulation of cytokine production involved in inflammatory response GO:19028833negative regulation of response to oxidative stress GO:0001503 ossification GO:0050673epithelial cell proliferation GO:0032501 multicellular organismal process GO:0051338"regulation of transferase activity GO:00346550nucleobase-containing compound catabolic process GO:0009058biosynthetic process GO:0050796regulation of insulin secretion GO:0010718;positive regulation of epithelial to mesenchymal transition GO:0071349#cellular response to interleukin-12 GO:0010243#response to organonitrogen compound GO:0009056catabolic process GO:0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0006692prostanoid metabolic process GO:0006693prostaglandin metabolic process GO:0006953acute-phase response GO:0070671response to interleukin-12 GO:0010467gene expression GO:00486627negative regulation of smooth muscle cell proliferation GO:0061028$establishment of endothelial barrier GO:0010821(regulation of mitochondrion organization GO:1904018.positive regulation of vasculature development GO:0009617response to bacterium GO:0001933.negative regulation of protein phosphorylation GO:0002711/positive regulation of T cell mediated immunity GO:00507318positive regulation of peptidyl-tyrosine phosphorylation GO:0009611response to wounding GO:0033002muscle cell proliferation GO:0070231T cell apoptotic process GO:1903573?negative regulation of response to endoplasmic reticulum stress GO:0071897DNA biosynthetic process GO:0048608"reproductive structure development GO:0070228*regulation of lymphocyte apoptotic process GO:0030155regulation of cell adhesion GO:0070374,positive regulation of ERK1 and ERK2 cascade GO:0045785$positive regulation of cell adhesion GO:0061458reproductive system development GO:0007169@transmembrane receptor protein tyrosine kinase signaling pathway GO:00482604positive regulation of receptor-mediated endocytosis GO:0006955immune response GO:0003012muscle system process GO:0022414reproductive process GO:0043412macromolecule modification GO:0043030#regulation of macrophage activation GO:0043525/positive regulation of neuron apoptotic process GO:0000003 reproduction GO:1901215#negative regulation of neuron death GO:0001306*age-dependent response to oxidative stress GO:0002352B cell negative selection GO:0002358 B cell homeostatic proliferation GO:0002384hepatic immune response GO:0003068?regulation of systemic arterial blood pressure by acetylcholine GO:0003070Bregulation of systemic arterial blood pressure by neurotransmitter GO:0007571'age-dependent general metabolic decline GO:0032625interleukin-21 production GO:0032665'regulation of interleukin-21 production GO:00327450positive regulation of interleukin-21 production GO:00355040regulation of myosin light chain kinase activity GO:00355059positive regulation of myosin light chain kinase activity GO:0060400@negative regulation of growth hormone receptor signaling pathway GO:0061741Mchaperone-mediated protein transport involved in chaperone-mediated autophagy GO:0072434@signal transduction involved in mitotic G2 DNA damage checkpoint GO:1900241+positive regulation of phenotypic switching GO:19026311negative regulation of membrane hyperpolarization GO:1902996-regulation of neurofibrillary tangle assembly GO:1903597,negative regulation of gap junction assembly GO:1904576response to tunicamycin GO:1904577 cellular response to tunicamycin GO:1904868*telomerase catalytic core complex assembly GO:19048828regulation of telomerase catalytic core complex assembly GO:1904884Apositive regulation of telomerase catalytic core complex assembly GO:19051780regulation of cardiac muscle tissue regeneration GO:19051799negative regulation of cardiac muscle tissue regeneration GO:2001228)regulation of response to gamma radiation GO:0046903 secretion GO:0048732gland development GO:0046700heterocycle catabolic process GO:0010830%regulation of myotube differentiation GO:0032768$regulation of monooxygenase activity GO:0045428/regulation of nitric oxide biosynthetic process GO:0051353.positive regulation of oxidoreductase activity GO:19047057regulation of vascular smooth muscle cell proliferation GO:1990874)vascular smooth muscle cell proliferation GO:0044270,cellular nitrogen compound catabolic process GO:0045935Gpositive regulation of nucleobase-containing compound metabolic process GO:00327314positive regulation of interleukin-1 beta production GO:0006259DNA metabolic process GO:0034613cellular protein localization GO:0034284response to monosaccharide GO:0045184%establishment of protein localization GO:0030073insulin secretion GO:0019439#aromatic compound catabolic process GO:0001817!regulation of cytokine production GO:0043434< response to peptide hormone GO:0009612response to mechanical stimulus GO:0051155;positive regulation of striated muscle cell differentiation GO:0050870(positive regulation of T cell activation GO:0002526acute inflammatory response GO:0001816cytokine production GO:0042326&negative regulation of phosphorylation GO:0090276'regulation of peptide hormone secretion GO:0002260lymphocyte homeostasis GO:0032757/positive regulation of interleukin-8 production GO:0048247lymphocyte chemotaxis GO:0070059Qintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0007420brain development GO:0008406gonad development GO:0010564 regulation of cell cycle process GO:0002720Fpositive regulation of cytokine production involved in immune response GO:0030595leukocyte chemotaxis GO:0010001glial cell differentiation GO:00511296negative regulation of cellular component organization GO:0002066-columnar/cuboidal epithelial cell development GO:0030888"regulation of B cell proliferation GO:0042093T-helper cell differentiation GO:00468242positive regulation of nucleocytoplasmic transport GO:19032011regulation of oxidative stress-induced cell death GO:0048762 mesenchymal cell differentiation GO:2001020-regulation of response to DNA damage stimulus GO:0090304nucleic acid metabolic process GO:0009266 response to temperature stimulus GO:0002699.positive regulation of immune effector process GO:0036498'IRE1-mediated unfolded protein response GO:00466260regulation of insulin receptor signaling pathway GO:0002697%regulation of immune effector process GO:1901361)organic cyclic compound catabolic process GO:0045137-development of primary sexual characteristics GO:0000082%G1/S transition of mitotic cell cycle GO:00061390nucleobase-containing compound metabolic process GO:0002294KCD4-positive, alpha-beta T cell differentiation involved in immune response GO:00022878alpha-beta T cell activation involved in immune response GO:0002293=alpha-beta T cell differentiation involved in immune response GO:0035914$skeletal muscle cell differentiation GO:0007050cell cycle arrest GO:0002532Bproduction of molecular mediator involved in inflammatory response GO:0042531?positive regulation of tyrosine phosphorylation of STAT protein GO:0043507*positive regulation of JUN kinase activity GO:0006469.negative regulation of protein kinase activity GO:1901991:negative regulation of mitotic cell cycle phase transition GO:19030393positive regulation of leukocyte cell-cell adhesion GO:0042110T cell activation GO:0051172:negative regulation of nitrogen compound metabolic process GO:0001885endothelial cell development GO:0032732/positive regulation of interleukin-1 production GO:0061180$mammary gland epithelium development GO:0033157-regulation of intracellular protein transport GO:1903706regulation of hemopoiesis GO:0002331pre-B cell allelic exclusion GO:0002904/positive regulation of B cell apoptotic process GO:0006808"regulation of nitrogen utilization GO:0021502neural fold elevation formation GO:0034021response to silicon dioxide GO:0034059response to anoxia GO:0048597,post-embryonic camera-type eye morphogenesis GO:00600576apoptotic process involved in mammary gland involution GO:0060058Mpositive regulation of apoptotic process involved in mammary gland involution GO:00605575positive regulation of vitamin D biosynthetic process GO:00605599positive regulation of calcidiol 1-monooxygenase activity GO:0061740Fprotein targeting to lysosome involved in chaperone-mediated autophagy GO:0070101;positive regulation of chemokine-mediated signaling pathway GO:00906795cell differentiation involved in phenotypic switching GO:0097026 dendritic cell dendrite assembly GO:0097694-establishment of RNA localization to telomere GO:0097695Destablishment of protein-containing complex localization to telomere GO:1902263;apoptotic process involved in embryonic digit morphogenesis GO:1902445\regulation of mitochondrial membrane permeability involved in programmed necrotic cell death GO:1902988neurofibrillary tangle assembly GO:1903519&regulation of mammary gland involution GO:1903521/positive regulation of mammary gland involution GO:1904578response to thapsigargin GO:1904579!cellular response to thapsigargin GO:1905420Lvascular smooth muscle cell differentiation involved in phenotypic switching GO:1905915Cregulation of cell differentiation involved in phenotypic switching GO:1905930Zregulation of vascular smooth muscle cell differentiation involved in phenotypic switching GO:2000547.regulation of dendritic cell dendrite assembly GO:2000634&regulation of primary miRNA processing GO:2000635/negative regulation of primary miRNA processing GO:0001894tissue homeostasis GO:0065008 regulation of biological quality GO:0090398cellular senescence GO:0019538protein metabolic process GO:0042593glucose homeostasis GO:0006809!nitric oxide biosynthetic process GO:0009743response to carbohydrate GO:0033500carbohydrate homeostasis GO:0045926negative regulation of growth GO:0048878chemical homeostasis GO:0051726regulation of cell cycle GO:0048871$multicellular organismal homeostasis GO:00022922T cell differentiation involved in immune response GO:0014015"positive regulation of gliogenesis GO:0070227lymphocyte apoptotic process GO:19000763regulation of cellular response to insulin stimulus GO:0097305response to alcohol GO:19019882negative regulation of cell cycle phase transition GO:0043407*negative regulation of MAP kinase activity GO:0030162regulation of proteolysis GO:0044843 cell cycle G1/S phase transition GO:0046209nitric oxide metabolic process GO:0072332;intrinsic apoptotic signaling pathway by p53 class mediator GO:0031349'positive regulation of defense response GO:2001057+reactive nitrogen species metabolic process GO:0030072peptide hormone secretion GO:0043491protein kinase B signaling GO:0033673&negative regulation of kinase activity GO:0050730/regulation of peptidyl-tyrosine phosphorylation GO:0030217T cell differentiation GO:0031100animal organ regeneration GO:0034103regulation of tissue remodeling GO:0048708astrocyte differentiation GO:19004073regulation of cellular response to oxidative stress GO:0046483heterocycle metabolic process GO:00512417negative regulation of multicellular organismal process GO:0002709&regulation of T cell mediated immunity GO:0071260(cellular response to mechanical stimulus GO:0050776regulation of immune response GO:0009636response to toxic substance GO:00425096regulation of tyrosine phosphorylation of STAT protein GO:0051205protein insertion into membrane GO:0001777 T cell homeostatic proliferation GO:0001922B-1 B cell homeostasis GO:0002408!myeloid dendritic cell chemotaxis GO:0003332Anegative regulation of extracellular matrix constituent secretion GO:0014805smooth muscle adaptation GO:0019740nitrogen utilization GO:0032286)central nervous system myelin maintenance GO:0045917,positive regulation of complement activation GO:00603558positive regulation of cell adhesion molecule production GO:0061030Nepithelial cell differentiation involved in mammary gland alveolus development GO:0061888"regulation of astrocyte activation GO:0070164,negative regulation of adiponectin secretion GO:0070318*positive regulation of G0 to G1 transition GO:0071000response to magnetism GO:00712112protein targeting to vacuole involved in autophagy GO:00970292mature conventional dendritic cell differentiation GO:0097296Zactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:1902202Aregulation of hepatocyte growth factor receptor signaling pathway GO:1902630(regulation of membrane< hyperpolarization GO:1905908/positive regulation of amyloid fibril formation GO:20002591positive regulation of protein activation cascade GO:2000676?positive regulation of type B pancreatic cell apoptotic process GO:0022008 neurogenesis GO:1901652response to peptide GO:0019915 lipid storage GO:0006725,cellular aromatic compound metabolic process GO:0017144drug metabolic process GO:0051091@positive regulation of DNA-binding transcription factor activity GO:0007260(tyrosine phosphorylation of STAT protein GO:0008625@extrinsic apoptotic signaling pathway via death domain receptors GO:1901224.positive regulation of NIK/NF-kappaB signaling GO:0048872homeostasis of number of cells GO:0007267cell-cell signaling GO:0060627(regulation of vesicle-mediated transport GO:0009791post-embryonic development GO:0032637interleukin-8 production GO:0032677&regulation of interleukin-8 production GO:0043367/CD4-positive, alpha-beta T cell differentiation GO:00519621positive regulation of nervous system development GO:0043506!regulation of JUN kinase activity GO:0036473*cell death in response to oxidative stress GO:00468891positive regulation of lipid biosynthetic process GO:0046883regulation of hormone secretion GO:0042446hormone biosynthetic process GO:0021700developmental maturation GO:0007548sex differentiation GO:0022409)positive regulation of cell-cell adhesion GO:1902882*regulation of response to oxidative stress GO:0050708regulation of protein secretion GO:0007005mitochondrion organization GO:0018193 peptidyl-amino acid modification GO:0060485mesenchyme development GO:0050778&positive regulation of immune response GO:1902105'regulation of leukocyte differentiation GO:1903827+regulation of cellular protein localization GO:0032611interleukin-1 beta production GO:0032651+regulation of interleukin-1 beta production GO:0032755/positive regulation of interleukin-6 production GO:0046427'positive regulation of JAK-STAT cascade GO:0007507heart development GO:0072331)signal transduction by p53 class mediator GO:00020236reduction of food intake in response to dietary excess GO:0002329pre-B cell differentiation GO:0002339B cell selection GO:0002434immune complex clearance GO:0010729=positive regulation of hydrogen peroxide biosynthetic process GO:0033092>positive regulation of immature T cell proliferation in thymus GO:00461360positive regulation of vitamin metabolic process GO:0060011Sertoli cell proliferation GO:0070487monocyte aggregation GO:0090261.positive regulation of inclusion body assembly GO:0090677reversible differentiation GO:00974111hypoxia-inducible factor-1alpha signaling pathway GO:19022628apoptotic process involved in blood vessel morphogenesis GO:1903377\negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1990834response to odorant GO:2000660?negative regulation of interleukin-1-mediated signaling pathway GO:0010035response to inorganic substance GO:0070542response to fatty acid GO:00107172regulation of epithelial to mesenchymal transition GO:1903530regulation of secretion by cell GO:0002367/cytokine production involved in immune response GO:0002718=regulation of cytokine production involved in immune response GO:0031058+positive regulation of histone modification GO:0045582-positive regulation of T cell differentiation GO:1904894#positive regulation of STAT cascade GO:1903047mitotic cell cycle process GO:00459362negative regulation of phosphate metabolic process GO:00105633negative regulation of phosphorus metabolic process GO:0071356*cellular response to tumor necrosis factor GO:0002690+positive regulation of leukocyte chemotaxis GO:0048232male gamete generation GO:0051348+negative regulation of transferase activity GO:00902879regulation of cellular response to growth factor stimulus GO:0097194execution phase of apoptosis GO:0034599%cellular response to oxidative stress GO:0060326cell chemotaxis GO:0010972<negative regulation of G2/M transition of mitotic cell cycle GO:0044057regulation of system process GO:0040007growth GO:00063038double-strand break repair via nonhomologous end joining GO:0032006regulation of TOR signaling GO:0045765regulation of angiogenesis GO:0033043$regulation of organelle organization GO:0032091&negative regulation of protein binding GO:0002248Mconnective tissue replacement involved in inflammatory response wound healing GO:00330914positive regulation of immature T cell proliferation GO:0033591response to L-ascorbic acid GO:0035234'ectopic germ cell programmed cell death GO:0035744#T-helper 1 cell cytokine production GO:00456276positive regulation of T-helper 1 cell differentiation GO:0046666"retinal cell programmed cell death GO:00603987regulation of growth hormone receptor signaling pathway GO:0061026"cardiac muscle tissue regeneration GO:0061419[positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061470(T follicular helper cell differentiation GO:0070162adiponectin secretion GO:0070163#regulation of adiponectin secretion GO:0071500'cellular response to nitrosative stress GO:0072679thymocyte migration GO:1900239"regulation of phenotypic switching GO:19029492positive regulation of tau-protein kinase activity GO:1903898>negative regulation of PERK-mediated unfolded protein response GO:1905323&telomerase holoenzyme complex assembly GO:20005541regulation of T-helper 1 cell cytokine production GO:2000556:positive regulation of T-helper 1 cell cytokine production GO:20006697negative regulation of dendritic cell apoptotic process GO:2001015;negative regulation of skeletal muscle cell differentiation GO:0015031protein transport GO:0051222(positive regulation of protein transport GO:1901360)organic cyclic compound metabolic process GO:1901575#organic substance catabolic process GO:0030593neutrophil chemotaxis GO:0070498(interleukin-1-mediated signaling pathway GO:0045930)negative regulation of mitotic cell cycle GO:0018105peptidyl-serine phosphorylation GO:0002456T cell mediated immunity GO:0042136%neurotransmitter biosynthetic process GO:1901564)organonitrogen compound metabolic process GO:0002791regulation of peptide secretion GO:0019725cellular homeostasis GO:0035710*CD4-positive, alpha-beta T cell activation GO:00511532regulation of striated muscle cell differentiation GO:0045786!negative regulation of cell cycle GO:0002250adaptive immune response GO:0051341%regulation of oxidoreductase activity GO:1901888$regulation of cell junction assembly GO:0071396cellular response to lipid GO:0034612!response to tumor necrosis factor GO:0043500muscle adaptation GO:0048640+negative regulation of developmental growth GO:00314003negative regulation of protein modification process GO:0046879hormone secretion GO:0000726non-recombinational repair GO:00027083positive regulation of lymphocyte mediated immunity GO:0032612interleukin-1 production GO:0032652&regulation of interleukin-1 production GO:0015833peptide transport GO:1903037*regulation of leukocyte cell-cell adhesion GO:0000425 pexophagy GO:0001842neural fold formation GO:0002246/wound healing involved in inflammatory response GO:0002606Ipositive regulation of dendritic cell antigen processing and presentation GO:0008635`activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0010726:positive regulation of hydrogen peroxide metabolic process GO:0031077*post-embryonic camera-type eye development GO:00313949positive regulation of prostaglandin biosynthetic process GO:0031622'positive regulation of fever generation GO:0036166phenotypic switching< GO:0043615astrocyte cell migration GO:0048050 post-embryonic eye morphogenesis GO:0051597response to methylmercury GO:00605580regulation of calcidiol 1-monooxygenase activity GO:1905065Bpositive regulation of vascular smooth muscle cell differentiation GO:1905461Opositive regulation of vascular associated smooth muscle cell apoptotic process GO:20006461positive regulation of receptor catabolic process GO:0030449#regulation of complement activation GO:0048259+regulation of receptor-mediated endocytosis GO:19027507negative regulation of cell cycle G2/M phase transition GO:0007346 regulation of mitotic cell cycle GO:0032496response to lipopolysaccharide GO:00105579positive regulation of macromolecule biosynthetic process GO:0002286-T cell activation involved in immune response GO:0046822)regulation of nucleocytoplasmic transport GO:20010226positive regulation of response to DNA damage stimulus GO:0045446 endothelial cell differentiation GO:0046632!alpha-beta T cell differentiation GO:2000278&regulation of DNA biosynthetic process GO:0071375-cellular response to peptide hormone stimulus GO:0009914hormone transport GO:0018209peptidyl-serine modification GO:0051188cofactor biosynthetic process GO:0006807#nitrogen compound metabolic process GO:0046677response to antibiotic GO:0050863regulation of T cell activation GO:0051046regulation of secretion GO:0016485protein processing GO:0042886amide transport GO:0051234establishment of localization GO:0006629lipid metabolic process GO:0002702Jpositive regulation of production of molecular mediator of immune response GO:0006096glycolytic process GO:0014902myotube differentiation GO:0072676lymphocyte migration GO:1901222%regulation of NIK/NF-kappaB signaling GO:0042742defense response to bacterium GO:0072330(monocarboxylic acid biosynthetic process GO:0002314&germinal center B cell differentiation GO:0006975*DNA damage induced protein phosphorylation GO:0035900response to isolation stress GO:0036480Lneuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:00480871positive regulation of developmental pigmentation GO:0051541elastin metabolic process GO:0061518microglial cell proliferation GO:00702442negative regulation of thymocyte apoptotic process GO:0071493cellular response to UV-B GO:0072321$chaperone-mediated protein transport GO:00900917positive regulation of extracellular matrix disassembly GO:0090400#stress-induced premature senescence GO:1903376Sregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1904354'negative regulation of telomere capping GO:1990264Wpeptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity GO:20006596regulation of interleukin-1-mediated signaling pathway GO:0006757ATP generation from ADP GO:0021782glial cell development GO:2000257(regulation of protein activation cascade GO:0010948)negative regulation of cell cycle process GO:0002237(response to molecule of bacterial origin GO:0007049 cell cycle GO:0002274myeloid leukocyte activation GO:1904951<positive regulation of establishment of protein localization GO:0034605cellular response to heat GO:0048593camera-type eye morphogenesis GO:0051209/release of sequestered calcium ion into cytosol GO:0043170macromolecule metabolic process GO:0006508 proteolysis GO:0040008regulation of growth GO:0022402cell cycle process GO:0033559(unsaturated fatty acid metabolic process GO:0042866pyruvate biosynthetic process GO:00512832negative regulation of sequestering of calcium ion GO:0032787%monocarboxylic acid metabolic process GO:0006913nucleocytoplasmic transport GO:0002688"regulation of leukocyte chemotaxis GO:0022612gland morphogenesis GO:0031929 TOR signaling GO:1990266neutrophil migration GO:0051193(regulation of cofactor metabolic process GO:0051282)regulation of sequestering of calcium ion GO:0051169nuclear transport GO:0007155 cell adhesion GO:0009057macromolecule catabolic process GO:0042493response to drug GO:00108221positive regulation of mitochondrion organization GO:0022610biological adhesion GO:0071621granulocyte chemotaxis GO:0001781neutrophil apoptotic process GO:00107284regulation of hydrogen peroxide biosynthetic process GO:0023041neuronal signal transduction GO:0031620regulation of fever generation GO:0032471Fnegative regulation of endoplasmic reticulum calcium ion concentration GO:0032906+transforming growth factor beta2 production GO:00329099regulation of transforming growth factor beta2 production GO:0036289#peptidyl-serine autophosphorylation GO:00436539mitochondrial fragmentation involved in apoptotic process GO:0045136/development of secondary sexual characteristics GO:0048563)post-embryonic animal organ morphogenesis GO:0060056mammary gland involution GO:0060556,regulation of vitamin D biosynthetic process GO:0061072iris morphogenesis GO:0071550)death-inducing signaling complex assembly GO:0071763nuclear membrane organization GO:1903596#regulation of gap junction assembly GO:19052888vascular associated smooth muscle cell apoptotic process GO:1905459Fregulation of vascular associated smooth muscle cell apoptotic process GO:2000553:positive regulation of T-helper 2 cell cytokine production GO:20010549negative regulation of mesenchymal cell apoptotic process GO:2001280Bpositive regulation of unsaturated fatty acid biosynthetic process GO:0044703#multi-organism reproductive process GO:0002449lymphocyte mediated immunity GO:0006690icosanoid metabolic process GO:0014013regulation of gliogenesis GO:0007159leukocyte cell-cell adhesion GO:00020651columnar/cuboidal epithelial cell differentiation GO:0048565digestive tract development GO:0051208sequestering of calcium ion GO:0042692muscle cell differentiation GO:00071670enzyme linked receptor protein signaling pathway GO:0034641,cellular nitrogen compound metabolic process GO:0045087innate immune response GO:0046031ADP metabolic process GO:0009887animal organ morphogenesis GO:0000278mitotic cell cycle GO:0044248cellular catabolic process GO:0003158endothelium development GO:0009306protein secretion GO:0072657 protein localization to membrane GO:0003006.developmental process involved in reproduction GO:0035690cellular response to drug GO:0002579:positive regulation of antigen processing and presentation GO:00033308regulation of extracellular matrix constituent secretion GO:00313920regulation of prostaglandin biosynthetic process GO:00330845regulation of immature T cell proliferation in thymus GO:0035860Aglial cell-derived neurotrophic factor receptor signaling pathway GO:0045141meiotic telomere clustering GO:0045625-regulation of T-helper 1 cell differentiation GO:00486429negative regulation of skeletal muscle tissue development GO:0051409response to nitrosative stress GO:0060068vagina development GO:0060353/regulation of cell adhesion molecule production GO:0070091glucagon secretion GO:0070092 regulation of glucagon secretion GO:00700992regulation of chemokine-mediated signaling pathway GO:0097048 dendritic cell apoptotic process GO:19030548negative regulation of extracellular matrix organization GO:1903715!regulation of aerobic respiration GO:2000668.regulation of dendritic cell apoptotic process GO:20006746regulation of type B pancreatic cell apoptotic process GO:0006886intracellular protein transport GO:0002920%regulation of humoral immune response GO:1905269-positive regulation of chromatin organization GO:0018108!peptidyl-tyrosine phosphorylation GO:0071496&cellular response to external stimulus GO:0018212peptidyl-tyrosine modification< GO:0006165&nucleoside diphosphate phosphorylation GO:0044255 cellular lipid metabolic process GO:0006959humoral immune response GO:00027052positive regulation of leukocyte mediated immunity GO:0042552 myelination GO:0043280Ypositive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0055123digestive system development GO:0046939nucleotide phosphorylation GO:0001660fever generation GO:0002604@regulation of dendritic cell antigen processing and presentation GO:0010248Festablishment or maintenance of transmembrane electrochemical gradient GO:0010269response to selenium ion GO:0031652&positive regulation of heat generation GO:0032308.positive regulation of prostaglandin secretion GO:0033080'immature T cell proliferation in thymus GO:0034397telomere localization GO:00400154negative regulation of multicellular organism growth GO:0042541hemoglobin biosynthetic process GO:0043619[regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0061517macrophage proliferation GO:0071044histone mRNA catabolic process GO:0071492cellular response to UV-A GO:0090220Ychromosome localization to nuclear envelope involved in homologous chromosome segregation GO:0097050(type B pancreatic cell apoptotic process GO:0097709connective tissue replacement GO:1902947)regulation of tau-protein kinase activity GO:1903800Opositive regulation of production of miRNAs involved in gene silencing by miRNA GO:19038975regulation of PERK-mediated unfolded protein response GO:1905907/negative regulation of amyloid fibril formation GO:2000434!regulation of protein neddylation GO:2000644(regulation of receptor catabolic process GO:20010530regulation of mesenchymal cell apoptotic process GO:2001269cpositive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0007272ensheathment of neurons GO:0008366axon ensheathment GO:0032635interleukin-6 production GO:0032675&regulation of interleukin-6 production GO:0042542response to hydrogen peroxide GO:1903531(negative regulation of secretion by cell GO:0007276gamete generation GO:00007247double-strand break repair via homologous recombination GO:0009135/purine nucleoside diphosphate metabolic process GO:00091793purine ribonucleoside diphosphate metabolic process GO:0010629&negative regulation of gene expression GO:0030879mammary gland development GO:0035264multicellular organism growth GO:0046425regulation of JAK-STAT cascade GO:00512480negative regulation of protein metabolic process GO:0000725recombinational repair GO:0008286"insulin receptor signaling pathway GO:0097553-calcium ion transmembrane import into cytosol GO:1901653cellular response to peptide GO:0008584male gonad development GO:0009185,ribonucleoside diphosphate metabolic process GO:0019216%regulation of lipid metabolic process GO:0033135-regulation of peptidyl-serine phosphorylation GO:00465462development of primary male sexual characteristics GO:0050921!positive regulation of chemotaxis GO:0001768 establishment of T cell polarity GO:0002327immature B cell differentiation GO:0006002&fructose 6-phosphate metabolic process GO:00109177negative regulation of mitochondrial membrane potential GO:0030242autophagy of peroxisome GO:0030656'regulation of vitamin metabolic process GO:00329664negative regulation of collagen biosynthetic process GO:0033083+regulation of immature T cell proliferation GO:0042368vitamin D biosynthetic process GO:00604521positive regulation of cardiac muscle contraction GO:00901548positive regulation of sphingolipid biosynthetic process GO:0097152"mesenchymal cell apoptotic process GO:20003044positive regulation of ceramide biosynthetic process GO:20012799regulation of unsaturated fatty acid biosynthetic process GO:1904892regulation of STAT cascade GO:0019359,nicotinamide nucleotide biosynthetic process GO:0019363(pyridine nucleotide biosynthetic process GO:0097530granulocyte migration GO:0060041%retina development in camera-type eye GO:0002790peptide secretion GO:0051604protein maturation GO:0001767$establishment of lymphocyte polarity GO:0001976Vneurological system process involved in regulation of systemic arterial blood pressure GO:0009886#post-embryonic animal morphogenesis GO:00106232programmed cell death involved in cell development GO:00107131negative regulation of collagen metabolic process GO:0030213hyaluronan biosynthetic process GO:0032306%regulation of prostaglandin secretion GO:0032494response to peptidoglycan GO:0033079immature T cell proliferation GO:0035745#T-helper 2 cell cytokine production GO:00360925phosphatidylinositol-3-phosphate biosynthetic process GO:0045837)negative regulation of membrane potential GO:00511529positive regulation of smooth muscle cell differentiation GO:0060352!cell adhesion molecule production GO:0070243)regulation of thymocyte apoptotic process GO:0070486leukocyte aggregation GO:0071481cellular response to X-ray GO:00724258signal transduction involved in G2 DNA damage checkpoint GO:0090594!inflammatory response to wounding GO:20005511regulation of T-helper 2 cell cytokine production GO:0001935endothelial cell proliferation GO:00725251pyridine-containing compound biosynthetic process GO:0031056"regulation of histone modification GO:00620137positive regulation of small molecule metabolic process GO:2001056;positive regulation of cysteine-type endopeptidase activity GO:0006090pyruvate metabolic process GO:0030856-regulation of epithelial cell differentiation GO:0042133"neurotransmitter metabolic process GO:0045580$regulation of T cell differentiation GO:0002706*regulation of lymphocyte mediated immunity GO:0046631alpha-beta T cell activation GO:0048592eye morphogenesis GO:0001771immunological synapse formation GO:00024682dendritic cell antigen processing and presentation GO:0030948Tnegative regulation of vascular endothelial growth factor receptor signaling pathway GO:0031053primary miRNA processing GO:0031650regulation of heat generation GO:0032725Rpositive regulation of granulocyte macrophage colony-stimulating factor production GO:00330897positive regulation of T cell differentiation in thymus GO:0034393;positive regulation of smooth muscle cell apoptotic process GO:0048070(regulation of developmental pigmentation GO:0060081membrane hyperpolarization GO:0060397=JAK-STAT cascade involved in growth hormone signaling pathway GO:0070141response to UV-A GO:0071639@positive regulation of monocyte chemotactic protein-1 production GO:0072540#T-helper 17 cell lineage commitment GO:1903799Onegative regulation of production of miRNAs involved in gene silencing by miRNA GO:1905906&regulation of amyloid fibril formation GO:19019901regulation of mitotic cell cycle phase transition GO:00458933positive regulation of transcription, DNA-templated GO:1903508;positive regulation of nucleic acid-templated transcription GO:1902680/positive regulation of RNA biosynthetic process GO:1901137,carbohydrate derivative biosynthetic process GO:0010876lipid localization GO:0044238primary metabolic process GO:0001678cellular glucose homeostasis GO:0007519"skeletal muscle tissue development GO:0009408response to heat GO:0071695anatomical structure maturation GO:0006816calcium ion transport GO:0030099myeloid cell differentiation GO:0051345)positive regulation of hydrolase activity GO:0060402"calcium ion transport into cytosol GO:00510907regulation of DNA-binding transcription factor activity GO:0009132(nucleoside diphosphate metabolic process GO:0034614,cellular response to reactive oxygen species GO:00903166positive regulation of intracellular prot<ein transport GO:0010715.regulation of extracellular matrix disassembly GO:0035791>platelet-derived growth factor receptor-beta signaling pathway GO:0042362(fat-soluble vitamin biosynthetic process GO:0045579-positive regulation of B cell differentiation GO:00480123hepatocyte growth factor receptor signaling pathway GO:19050639regulation of vascular smooth muscle cell differentiation GO:0030855epithelial cell differentiation GO:0022407 regulation of cell-cell adhesion GO:0002700Aregulation of production of molecular mediator of immune response GO:0006754ATP biosynthetic process GO:0051048 negative regulation of secretion GO:0051092>positive regulation of NF-kappaB transcription factor activity GO:1905952 regulation of lipid localization GO:00459449positive regulation of transcription by RNA polymerase II GO:0051100negative regulation of binding GO:0032386%regulation of intracellular transport GO:0046661male sex differentiation GO:0034248.regulation of cellular amide metabolic process GO:0006089lactate metabolic process GO:0019896!axonal transport of mitochondrion GO:0020027hemoglobin metabolic process GO:0030540female genitalia development GO:0032310prostaglandin secretion GO:0032604;granulocyte macrophage colony-stimulating factor production GO:0032645Iregulation of granulocyte macrophage colony-stimulating factor production GO:0033151V(D)J recombination GO:00341165positive regulation of heterotypic cell-cell adhesion GO:0042159lipoprotein catabolic process GO:0043217myelin maintenance GO:00459892positive regulation of striated muscle contraction GO:0051044>positive regulation of membrane protein ectodomain proteolysis GO:00612981retina vasculature development in camera-type eye GO:0061684chaperone-mediated autophagy GO:0071361cellular response to ethanol GO:1900102Fnegative regulation of endoplasmic reticulum unfolded protein response GO:1901741&positive regulation of myoblast fusion GO:1904262&negative regulation of TORC1 signaling GO:0060538!skeletal muscle organ development GO:0044237cellular metabolic process GO:0006665sphingolipid metabolic process GO:0043409#negative regulation of MAPK cascade GO:0046394$carboxylic acid biosynthetic process GO:0016053!organic acid biosynthetic process GO:0045766#positive regulation of angiogenesis GO:0071705nitrogen compound transport GO:0002830-positive regulation of type 2 immune response GO:0006978oDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0010224response to UV-B GO:00108296negative regulation of glucose transmembrane transport GO:0016264gap junction assembly GO:0030730sequestering of triglyceride GO:00335999regulation of mammary gland epithelial cell proliferation GO:0043517Upositive regulation of DNA damage response, signal transduction by p53 class mediator GO:0045779&negative regulation of bone resorption GO:0048569'post-embryonic animal organ development GO:0050665&hydrogen peroxide biosynthetic process GO:0060644-mammary gland epithelial cell differentiation GO:00702303positive regulation of lymphocyte apoptotic process GO:0071850mitotic cell cycle arrest GO:0090083%regulation of inclusion body assembly GO:1900221$regulation of amyloid-beta clearance GO:2001267Zregulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0006810 transport GO:0003008system process GO:0023061signal release GO:00092067purine ribonucleoside triphosphate biosynthetic process GO:0007088&regulation of mitotic nuclear division GO:00091453purine nucleoside triphosphate biosynthetic process GO:0038061NIK/NF-kappaB signaling GO:0006956complement activation GO:0071346%cellular response to interferon-gamma GO:1901987)regulation of cell cycle phase transition GO:0046890(regulation of lipid biosynthetic process GO:0002295 T-helper cell lineage commitment GO:0002902&regulation of B cell apoptotic process GO:0030889+negative regulation of B cell proliferation GO:0031643"positive regulation of myelination GO:0031649heat generation GO:0032305*positive regulation of icosanoid secretion GO:0042772CDNA damage response, signal transduction resulting in transcription GO:0043691reverse cholesterol transport GO:0051895.negative regulation of focal adhesion assembly GO:0060965.negative regulation of gene silencing by miRNA GO:1902004-positive regulation of amyloid-beta formation GO:1902430-negative regulation of amyloid-beta formation GO:2000303+regulation of ceramide biosynthetic process GO:0010950-positive regulation of endopeptidase activity GO:0030324lung development GO:00518971positive regulation of protein kinase B signaling GO:0051254,positive regulation of RNA metabolic process GO:1901568'fatty acid derivative metabolic process GO:0055082cellular chemical homeostasis GO:00092010ribonucleoside triphosphate biosynthetic process GO:0051053,negative regulation of DNA metabolic processgeneNamePITARNA22miRmapmicroTmiRandaPicTar TargetScan hsa-let-7a-5pCDKN1A hsa-let-7b-5p hsa-let-7c-5p hsa-let-7e-5p hsa-let-7f-5p hsa-miR-17-5phsa-miR-20a-5p hsa-miR-22-3p hsa-miR-28-5p hsa-miR-93-5p hsa-miR-98-5phsa-miR-106a-5phsa-miR-224-5p hsa-let-7g-5p hsa-let-7i-5phsa-miR-130a-3phsa-miR-106b-5phsa-miR-301a-3phsa-miR-130b-3phsa-miR-365a-3phsa-miR-370-3phsa-miR-20b-5phsa-miR-485-5phsa-miR-526b-3phsa-miR-519d-3phsa-miR-499a-5phsa-miR-454-3phsa-miR-708-5phsa-miR-301b-3pHIF1Ahsa-miR-18a-5phsa-miR-19a-3phsa-miR-19b-3phsa-miR-199a-5phsa-miR-199b-5phsa-miR-135a-5phsa-miR-138-5phsa-miR-155-5phsa-miR-376c-3phsa-miR-151a-3phsa-miR-135b-5phsa-miR-338-3phsa-miR-18b-5phsa-miR-433-3phsa-miR-582-5p hsa-miR-613hsa-miR-660-5phsa-miR-488-3p hsa-miR-1179 hsa-miR-1276hsa-miR-4735-3pMXD1 hsa-let-7d-5phsa-miR-29a-3p hsa-miR-31-5phsa-miR-101-3phsa-miR-29b-3phsa-miR-148a-3p hsa-miR-147a hsa-miR-1-3phsa-miR-124-3p hsa-miR-137hsa-miR-152-3phsa-miR-146a-5phsa-miR-149-5phsa-miR-186-5phsa-miR-194-5p hsa-miR-206hsa-miR-29c-3phsa-miR-302a-3phsa-miR-302b-3phsa-miR-302c-3phsa-miR-302d-3phsa-miR-372-3phsa-miR-373-3phsa-miR-148b-3phsa-miR-410-3phsa-miR-146b-5phsa-miR-495-3p hsa-miR-520ehsa-miR-520a-5phsa-miR-520a-3phsa-miR-525-5phsa-miR-520d-3phsa-miR-625-5phsa-miR-758-3p hsa-miR-302e hsa-miR-4458hsa-miR-129-5pSOD2hsa-miR-212-3phsa-miR-132-3phsa-miR-144-3phsa-miR-377-3phsa-miR-382-5p miRNAname 7Table S3 miRNA prediction 7 miRNA-target predicting programs9Supplementary Table 1. 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